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PD-1 signaling
Stable Identifier
R-HSA-389948
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
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The Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation events that are positively regulated by CD28 or indirectly through IL-2. PD-1 ligation inhibits the induction of the cell survival factor Bcl-xL and the expression of transcription factors associated with effector cell function, including GATA-3, Tbet, and Eomes. PD-1 exerts its inhibitory effects by bringing phosphatases SHP-1 and SHP-2 into the immune synapse, leading to dephosphorylation of CD3-zeta chain, PI3K and AKT.
Literature References
PubMed ID
Title
Journal
Year
18759926
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
Fife, BT
,
Bluestone, JA
Immunol Rev
2008
18173375
PD-1 and its ligands in tolerance and immunity
Keir, ME
,
Sharpe, AH
,
Freeman, GJ
,
Butte, MJ
Annu Rev Immunol
2008
Participants
Events
PD-1 binds B7DC and B7H1
(Homo sapiens)
PDCD1 binds PDCD1 inhibitors
(Homo sapiens)
Phosphorylation of PD-1
(Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1
(Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
(Homo sapiens)
Participates
as an event of
Costimulation by the CD28 family (Homo sapiens)
Orthologous Events
PD-1 signaling (Bos taurus)
PD-1 signaling (Canis familiaris)
PD-1 signaling (Gallus gallus)
PD-1 signaling (Mus musculus)
PD-1 signaling (Rattus norvegicus)
PD-1 signaling (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000724
Authored
Garapati, P V (2008-12-16)
Reviewed
Bluestone, JA (2009-06-01)
Esensten, J (2009-06-01)
Created
Garapati, P V (2009-01-21)
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