Reactome | Interaction of SHP-1 or SHP-2 with phospho PD-1

Interaction of SHP-1 or SHP-2 with phospho PD-1

Stable Identifier

R-HSA-389759

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Interaction of SHP-1 or SHP-2 with phospho PD-1

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Once phosphorylated, SH2-domain-containing tyrosine phosphatases SHP-1 and SHP-2 bind to the Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and the Immunoreceptor Tyrosine-based Switch Motif (ITSM) of PD-1. This interaction is crucial for PD-1's inhibitory signaling pathway. Both phosphatases play significant roles in modulating T cell responses by dephosphorylating key signaling molecules involved in T cell activation. SHP-2, in particular, contributes to the attenuation of T cell receptor (TCR) signaling by dephosphorylating molecules such as CD3-zeta and PI3K, leading to reduced activation and proliferation of T cells (Chemnitz 1 et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
18759926	Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Fife, BT, Bluestone, JA	Immunol Rev	2008
18173375	PD-1 and its ligands in tolerance and immunity Keir, ME, Sharpe, AH, Freeman, GJ, Butte, MJ	Annu Rev Immunol	2008