The cytoplasmic domain of PD-1 has two tyrosine motifs, ITIM and ITSM. On engagement with B7 ligands B7DC and B7H1, PD-1 is phosphorylated on tyrosine residues 223 and 248 within these motifs. Kinases Lck and Csk also bind to these motifs and these kinases may be involved in the phosphorylation of PD-1.
Fife, BT, Bluestone, JA
Keir, ME, Sharpe, AH, Freeman, GJ, Butte, MJ
Carter, LL, Carreno, BM
protein tyrosine kinase activity of LCK, CSK [cytosol]
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