Phosphorylation of PD-1

Stable Identifier
R-HSA-389762
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of PD-1
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The cytoplasmic domain of PD-1 has two tyrosine motifs, ITIM and ITSM. On engagement with B7 ligands B7DC and B7H1, PD-1 is phosphorylated on tyrosine residues 223 and 248 within these motifs. Kinases Lck and Csk also bind to these motifs and these kinases may be involved in the phosphorylation of PD-1.

Literature References
PubMed ID Title Journal Year
18173375 PD-1 and its ligands in tolerance and immunity

Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH

Annu Rev Immunol 2008
18759926 Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

Fife, BT, Bluestone, JA

Immunol Rev 2008
12947224 Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Carter, LL, Carreno, BM

Immunol Res 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LCK, CSK [cytosol]
Physical Entity
LCK, CSK [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of PD-1 (Bos taurus)
Phosphorylation of PD-1 (Canis familiaris)
Phosphorylation of PD-1 (Mus musculus)
Phosphorylation of PD-1 (Rattus norvegicus)
Phosphorylation of PD-1 (Sus scrofa)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-13)