Phosphorylation of PD-1

Stable Identifier
R-HSA-389762
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of PD-1
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The cytoplasmic domain of PD-1 has two tyrosine motifs, ITIM and ITSM. On engagement with B7 ligands B7DC and B7H1, PD-1 is phosphorylated on tyrosine residues 223 and 248 within these motifs. Kinases Lck and Csk also bind to these motifs and these kinases may be involved in the phosphorylation of PD-1.

Literature References
PubMed ID Title Journal Year
18759926 Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

Fife, BT, Bluestone, JA

Immunol Rev 2008
18173375 PD-1 and its ligands in tolerance and immunity

Keir, ME, Sharpe, AH, Freeman, GJ, Butte, MJ

Annu Rev Immunol 2008
12947224 Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Carter, LL, Carreno, BM

Immunol Res 2003
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of LCK, CSK [cytosol]

Physical Entity
LCK, CSK [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of PD-1 (Bos taurus)
Phosphorylation of PD-1 (Canis familiaris)
Phosphorylation of PD-1 (Gallus gallus)
Phosphorylation of PD-1 (Mus musculus)
Phosphorylation of PD-1 (Rattus norvegicus)
Phosphorylation of PD-1 (Sus scrofa)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-13)
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