Reactome | Phosphorylation of PD-1

Phosphorylation of PD-1

Stable Identifier

R-HSA-389762

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The cytoplasmic domain of PD-1 has two tyrosine motifs, ITIM and ITSM. On engagement with B7 ligands B7DC and B7H1, PD-1 is phosphorylated on tyrosine residues 223 and 248 within these motifs. Kinases Lck and Csk also bind to these motifs and these kinases may be involved in the phosphorylation of PD-1.

Literature References

PubMed ID	Title	Journal	Year
18173375	PD-1 and its ligands in tolerance and immunity Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH	Annu Rev Immunol	2008
18759926	Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Fife, BT, Bluestone, JA	Immunol Rev	2008
12947224	Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation Carter, LL, Carreno, BM	Immunol Res	2003