PD-1 binds B7DC and B7H1

Stable Identifier
R-HSA-388828
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PD-1 binds B7DC and B7H1
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The Programmed cell death protein 1 (PD-1) is functionally similar to CTLA4 and exerts an inhibitory signal on T cell activation. PD-1 binds the ligands B7H1 and B7DC but with different affinities. Interaction of PD-1/B7DC exhibited a 2-6-fold higher affinity and had different association/dissociation kinetics compared with the interaction of PD-1/B7H1.
Literature References
PubMed ID Title Journal Year
12893276 Differential binding properties of B7-H1 and B7-DC to programmed death-1

Kozono, Y, Azuma, M, Jin, H, Youngnak, P, Otsuki, N, Omura, K, Kozono, H, Chen, L, Pardoll, DM, Iwai, H, Yagita, H

Biochem Biophys Res Commun 2003
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
This event is regulated
Negatively by
Regulator
PDCD1:PDCD1 inhibitors [plasma membrane] (Homo sapiens)
Orthologous Events
PD-1 binds B7DC and B7H1 (Bos taurus)
PD-1 binds B7DC and B7H1 (Canis familiaris)
PD-1 binds B7DC and B7H1 (Gallus gallus)
PD-1 binds B7DC and B7H1 (Mus musculus)
PD-1 binds B7DC and B7H1 (Rattus norvegicus)
PD-1 binds B7DC and B7H1 (Sus scrofa)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)
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