The Programmed cell death protein 1 (PD-1) is functionally similar to CTLA4 and exerts an inhibitory signal on T cell activation. PD-1 binds the ligands B7H1 and B7DC but with different affinities. Interaction of PD-1/B7DC exhibited a 2-6-fold higher affinity and had different association/dissociation kinetics compared with the interaction of PD-1/B7H1.
Kozono, Y, Azuma, M, Jin, H, Youngnak, P, Otsuki, N, Omura, K, Kozono, H, Chen, L, Pardoll, DM, Iwai, H, Yagita, H
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