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PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
Stable Identifier
R-HSA-388784
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 homodimer binds B7-1 homodimer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CD28 homodimer binds B7-2 monomer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Participants
components
B7-1 homodimer/ B7-2 [plasma membrane]
(Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane]
(Homo sapiens)
Participates
as an output of
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
as an input of
Phosphorylation of CTLA-4 (Homo sapiens)
This entity regulates
Negatively
CD28 homodimer binds B7-1 homodimer
(Homo sapiens)
CD28 homodimer binds B7-2 monomer
(Homo sapiens)
Inferred To
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Bos taurus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Canis familiaris)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Gallus gallus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Mus musculus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Rattus norvegicus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Sus scrofa)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
(Xenopus tropicalis)
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