CD28 homodimer binds B7-2 monomer

Stable Identifier
Reaction [binding]
Homo sapiens
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CD28 delivers the costimulatory signal by interacting with its ligand B7-2 on the antigen-presenting cell and modulates T cell antigen recognition. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligand B7-2. Engagement of CD28 with B7-1 and with B7-2 have different bilogical functions in-vivo. Rapid dissociation of B7-2 from CD28 may not permit the robust tyrosine phosphorylation that the prolonged binding of B7-1 induces.

Literature References
PubMed ID Title Journal Year
8649453 Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis

Couez, D, Olive, D, Hurle, MR, Eichman, C, Sweet, R, Lyn, SD, Ryan, P, Sekaly, RP, Reddy, M, Truneh, A

Mol Immunol 1996
8609386 Interactions of CD80 and CD86 with CD28 and CTLA4

Crowe, JS, Vinogradov, DV, Linge, C, Ellis, JH, Burden, MN

J Immunol 1996
Orthologous Events
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