Reactome | CD28 homodimer binds B7-2 monomer

CD28 homodimer binds B7-2 monomer

Stable Identifier

R-HSA-388808

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CD28 delivers the costimulatory signal by interacting with its ligand B7-2 on the antigen-presenting cell and modulates T cell antigen recognition. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligand B7-2. Engagement of CD28 with B7-1 and with B7-2 have different bilogical functions in-vivo. Rapid dissociation of B7-2 from CD28 may not permit the robust tyrosine phosphorylation that the prolonged binding of B7-1 induces.

Literature References

PubMed ID	Title	Journal	Year
8649453	Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis Couez, D, Olive, D, Hurle, MR, Eichman, C, Sweet, R, Lyn, SD, Ryan, P, Sekaly, RP, Reddy, M, Truneh, A	Mol Immunol	1996
8609386	Interactions of CD80 and CD86 with CD28 and CTLA4 Crowe, JS, Vinogradov, DV, Linge, C, Ellis, JH, Burden, MN	J Immunol	1996