Phosphorylation of CTLA-4

Stable Identifier
R-HSA-388833
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of CTLA-4
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Upon TCR-CTLA-4 complex formation, CTLA4 is tyrosine phosphorylated. Src family tyrosine kinases Fyn, Lyn, and Lck associate with CTLA-4 and phosphorylate both Y-165 and Y-182 that are mainly responsible for interaction with Fyn through its SH2 domain. Once tyrosine 165 is phosphorylated, PP2A is activated and disassociates from CTLA4; this correlates with T cell inactivation.

Literature References
PubMed ID Title Journal Year
11994459 Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

Baroja, ML, Vijayakrishnan, L, Bettelli, E, Darlington, PJ, Chau, TA, Ling, V, Collins, M, Carreno, BM, Madrenas, J, Kuchroo, VK

J Immunol 2002
9712716 Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)

Miyatake, S, Nakaseko, C, Umemori, H, Yamamoto, T, Saito, T

Biochem Biophys Res Commun 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]
Physical Entity
Src family tyrosine kinases (SFKs) [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of CTLA-4 (Gallus gallus)
Phosphorylation of CTLA-4 (Mus musculus)
Phosphorylation of CTLA-4 (Rattus norvegicus)
Phosphorylation of CTLA-4 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)