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B7-1 homodimer/ B7-2 [plasma membrane]
Stable Identifier
R-HSA-388762
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
CD28:B7-1,B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
SHP2 phosphatase binds CTLA-4 (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
Participants
members
CD80 (B7-1) homodimer [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Participant Of
input
CTLA-4 binds B7-1/B7-2
hasComponent
CD28:B7-1,B7-2 [plasma membrane]
p-Y165,Y182-CTLA4 dimer:B7-1/B7-2 [plasma membrane]
phospho CD28:B7-1/B7-2 [plasma membrane]
PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
Inferred To
B7-1 homodimer/ B7-2 [plasma membrane] (Bos taurus)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Danio rerio)
B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
B7-1 homodimer/ B7-2 [plasma membrane] (Mus musculus)
B7-1 homodimer/ B7-2 [plasma membrane] (Rattus norvegicus)
B7-1 homodimer/ B7-2 [plasma membrane] (Sus scrofa)
B7-1 homodimer/ B7-2 [plasma membrane] (Xenopus tropicalis)
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