CTLA-4 binds B7-1/B7-2

Stable Identifier
Homo sapiens
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CTLA4 binds with high affinity to the ligands B71 and B72. The interaction of B7 molecules with CTLA4 provides inhibitory signals required for downregulation of the TCR response. The interaction is mediated by the CDR3 analogous loop of CTLA4, composed of an MYPPY motif, with a concave surface on the B7 formed predominately by the G, F, C, C' and C" strands. Its also been demonstrated that B7 binding is not totally essential for CTLA-4 activity.

Literature References
PubMed ID Title Journal Year
10799894 Structural analysis of CTLA-4 function in vivo

Masteller, EL, Reiner, SL, Chuang, E, Mullen, AC, Thompson, CB

J Immunol 2000
15142525 An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

Hafler, DA, Sharpe, AH, Greve, B, Peterson, LB, Vijayakrishnan, L, Freeman, GJ, Slavik, JM, Greenwald, RJ, Rainbow, D, Kuchroo, VK, Ill├ęs, Z, Wicker, LS

Immunity 2004
11976720 Structural mechanisms of costimulation

Zhang, X, Schwartz, JC, Nathenson, SG, Almo, SC

Nat Immunol 2002
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