Reactome | CTLA-4 binds B7-1/B7-2

CTLA-4 binds B7-1/B7-2

Stable Identifier

R-HSA-388809

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CTLA4 binds with high affinity to the ligands B71 and B72. The interaction of B7 molecules with CTLA4 provides inhibitory signals required for downregulation of the TCR response. The interaction is mediated by the CDR3 analogous loop of CTLA4, composed of an MYPPY motif, with a concave surface on the B7 formed predominately by the G, F, C, C' and C" strands. Its also been demonstrated that B7 binding is not totally essential for CTLA-4 activity.

Literature References

PubMed ID	Title	Journal	Year
10799894	Structural analysis of CTLA-4 function in vivo Masteller, EL, Reiner, SL, Chuang, E, Mullen, AC, Thompson, CB	J Immunol	2000
15142525	An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells Hafler, DA, Sharpe, AH, Greve, B, Peterson, LB, Vijayakrishnan, L, Freeman, GJ, Slavik, JM, Greenwald, RJ, Rainbow, D, Kuchroo, VK, Illés, Z, Wicker, LS	Immunity	2004
11976720	Structural mechanisms of costimulation Zhang, X, Schwartz, JC, Nathenson, SG, Almo, SC	Nat Immunol	2002