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phospho CD28:B7-1/B7-2 [plasma membrane]
Stable Identifier
R-HSA-388777
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Participants
components
B7-1 homodimer/ B7-2 [plasma membrane]
(Homo sapiens)
x 2
FYN,LCK [cytosol]
(Homo sapiens)
Phospho CD28 homodimer [plasma membrane]
(Homo sapiens)
Participates
as a component of
CD28:GRAP2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
as an input of
Gads binds CD28 (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
as an output of
Phosphorylation of CD28 (Homo sapiens)
Inferred To
phospho CD28:B7-1/B7-2 [plasma membrane]
(Bos taurus)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Rattus norvegicus)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane]
(Xenopus tropicalis)
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