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B7-1 homodimer/ B7-2 [plasma membrane]
Stable Identifier
R-CFA-388762
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Cdc42 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Activation of Rac1 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Activation of Vav1 (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Grb2 binds CD28 (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Translocation of Vav1 to CD28 (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
CD28:Grb2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Gads binds CD28 (Canis familiaris)
CD28:GRAP2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Phosphorylation of CD28 (Canis familiaris)
CD28:B7-1,B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
CTLA4 inhibitory signaling (Canis familiaris)
CTLA-4 binds B7-1/B7-2 (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Phosphorylation of CTLA-4 (Canis familiaris)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
SHP2 phosphatase binds CTLA-4 (Canis familiaris)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Canis familiaris)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
Participants
members
CD80 dimer [plasma membrane]
(Canis familiaris)
CD86 [plasma membrane]
(Canis familiaris)
Participates
as an input of
CTLA-4 binds B7-1/B7-2 (Canis familiaris)
as a component of
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
CD28:B7-1,B7-2 [plasma membrane] (Canis familiaris)
phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
Inferred From
B7-1 homodimer/ B7-2 [plasma membrane]
(Homo sapiens)
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