Reactome | GCG [extracellular region]

GCG [extracellular region]

Stable Identifier

R-BTA-381699

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

ArgN-GCG(98-127), P01272

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (s) signalling events (Bos taurus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GLP-1:GLP-1R [plasma membrane] (Bos taurus)
        
        GCG [extracellular region] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GLP-1:GLP-1R [plasma membrane] (Bos taurus)
        
        GCG [extracellular region] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class B/2 (Secretin family receptors) (Bos taurus)
      - Glucagon-type ligand receptors (Bos taurus)
        
        GLP1R binds GLP1 (Bos taurus)
        
        GCG [extracellular region] (Bos taurus)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Bos taurus)
        
        GLP-1:GLP-1R [plasma membrane] (Bos taurus)
        
        GCG [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:P01272

Gene Names

GCG

Reference Genes

BioGPS Gene:280802 GCG

ENSEMBL:ENSBTAG00000000730

ENSEMBL:ENSBTAG00000000730.4 GCG

KEGG Gene (Bos taurus):280802 GCG

Monarch:280802 GCG

NCBI Gene:280802 GCG

Reference Transcript

RefSeq:NM_173916.3 GCG

Other Identifiers

280802

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0005975

GO:0006094

GO:0007189

GO:0010737

GO:0010800

GO:0012501

GO:0014823

GO:0023052

GO:0033138

GO:0035774

GO:0036211

GO:0042593

GO:0042802

GO:0043066

GO:0045722

GO:0048018

GO:0050796

GO:0051571

GO:0070374

GO:0071377

GO:0090280

GO:0098772

GO:1900118

Participates

as an input of

as an output of

Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)

as a component of

GLP-1:GLP-1R [plasma membrane] (Bos taurus)

Other forms of this molecule

GCG [extracellular region]

GCG [endoplasmic reticulum lumen]

GCG [secretory granule lumen]

GCG [extracellular region]

Inferred From

mature GLP1 [extracellular region] (Homo sapiens)

ArgN-GCG(98-127) [extracellular region] (Homo sapiens)

Modified Residues

Name

L-arginine amide at 127 (in Homo sapiens)

Coordinate

127

PsiMod Name

L-arginine amide [MOD:00091]

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to L-arginine amide.

Cross References

RefSeq

NP_776341.1

OpenTargets

ENSG00000115263

Ensembl

ENSBTAG00000000730, ENSBTAP00000000972, ENSBTAT00000000972

VGNC

29284

PDB

1KX6