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PLK4 [cytosol]
Stable Identifier
R-HSA-380286
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Association of NuMA with microtubules (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Translocation of NuMA to the centrosomes (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 binds AURKA at centrosomes (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome maturation (Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
Loss of C-Nap-1 from centrosomes (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Plk1-mediated phosphorylation of Nlp (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
Recruitment of CDK11p58 to the centrosomes (Homo sapiens)
Centrosomes containing recruited CDK11p58 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
Centrosome associated Plk1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AJUBA binds centrosome-associated AURKA (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Anchoring of the basal body to the plasma membrane (Homo sapiens)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
C2CD3 binds the mother centriole (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
CP110 and CEP97 dissociate from the centriole (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
MARK4 binds ODF2 in the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Recruitment of transition zone proteins (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
The distal appendage proteins recruit TTBK2 (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00444 PLK4
Gene Names
PLK4, SAK, STK18
Chain
chain:1-970
Reference Genes
BioGPS Gene:10733 PLK4
COSMIC (genes):PLK4 PLK4
CTD Gene:10733 PLK4
dbSNP Gene:10733 PLK4
ENSEMBL:ENSG00000142731 PLK4
ENSEMBL_homo_sapiens_GENE:ENSG00000142731 PLK4
HGNC:11397 PLK4
KEGG Gene (Homo sapiens):10733 PLK4
Monarch:10733 PLK4
NCBI Gene:10733 PLK4
OMIM:605031 PLK4
UCSC:O00444 PLK4
Reference Transcript
RefSeq:NM_001190801.1 PLK4
RefSeq:NM_014264.4 PLK4
RefSeq:NM_001190799.1 PLK4
Other Identifiers
0001050546
10733
11732242_a_at
11747114_a_at
16970563
17327
204886_at
204887_s_at
211088_s_at
2742986
2742987
2742988
2742993
2742994
2742997
2742998
2743000
2743001
2743002
2743003
2743004
2743005
2743007
2743008
2743009
2743010
2743012
2743013
2743014
2743015
2743016
2743017
2743018
2743019
2743020
2743021
2743022
2N19
32703_at
35026
3COK
4068436
43198
4JXF
4N7V
4N7Z
4N9J
4YUR
4YYP
5LHY
5LHZ
8097356
82748_at
975_at
A_14_P105267
A_14_P125392
A_23_P155969
A_24_P912925
AAH36023
AB006972
AK302858
AK303399
AK314238
BAB69958
BAG36907
BAH13823
BAH13953
BC036023
CAA73575
CCDS3735
CCDS54803
CCDS54804
ENSG00000142731
ENSP00000270861
ENSP00000423582
ENSP00000427554
ENST00000270861
ENST00000513090
ENST00000514379
EntrezGene:10733
g405744_3p_s_at
g7657626_3p_a_at
GE60304
GO:0000003
GO:0000086
GO:0000166
GO:0000278
GO:0001741
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006468
GO:0007010
GO:0007049
GO:0007099
GO:0008150
GO:0009790
GO:0010389
GO:0016301
GO:0016310
GO:0016740
GO:0022607
GO:0030154
GO:0032154
GO:0042802
GO:0043167
GO:0043226
GO:0046601
GO:0048856
GO:0060707
GO:0097711
GO:0098535
GO:0098536
H0YAL6
HGNC:11397
HPA017327
HPA035026
HPA043198
ILMN_1789123
IPR000719
IPR000959
IPR008266
IPR011009
IPR017441
IPR033696
IPR033698
IPR033699
IPR033700
J3KR82
J3KR84
MIM:605031
MIM:616171
NM_001190799
NM_001190801
NM_014264
NP_001177728
NP_001177730
NP_055079
PF00069
PF00659
PH_hs_0010304
PLK4
PLK4-201
PLK4-209
PLK4-210
TC04000645.hg
uc003ifo.4
uc011cgs.3
uc011cgt.3
UPI000007426E
UPI0000422B71
UPI0001B30121
XM_005262701
XM_017007662
XM_017007663
XP_005262758
XP_016863151
XP_016863152
Y13115
Y13115_at
Participant Of
hasComponent
centrosome [cytosol]
centrosome containing phosphorylated Nlp [cytosol]
centrosome without CEP164, CCP110 or CEP97 [cytosol]
cNAP-1 depleted centrosome [cytosol]
mother centriole [cytosol]
Nlp-depleted centrosome [cytosol]
Inferred To
Homologues of PLK4 [cytosol] (Canis familiaris)
Homologues of PLK4 [cytosol] (Gallus gallus)
Homologues of PLK4 [cytosol] (Xenopus tropicalis)
PLK4 [cytosol] (Bos taurus)
PLK4 [cytosol] (Canis familiaris)
PLK4 [cytosol] (Danio rerio)
PLK4 [cytosol] (Gallus gallus)
PLK4 [cytosol] (Mus musculus)
PLK4 [cytosol] (Rattus norvegicus)
PLK4 [cytosol] (Taeniopygia guttata)
PLK4 [cytosol] (Xenopus tropicalis)
Ghost homologue of PLK4 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_001177728.1
,
NP_001177730.1
,
NP_055079.3
ZINC - World Drugs
PLK4_HUMAN
OpenTargets
ENSG00000142731
ZINC - FDA approved
PLK4_HUMAN
ZINC - Substances
PLK4_HUMAN
ZINC - Biogenic
PLK4_HUMAN
ZINC target
O00444
PRO
O00444
PDB
2N19
,
4JXF
,
5LHZ
,
5LHY
,
4YUR
,
3COK
,
4YYP
,
4N7V
,
4N9J
,
4N7Z
ZINC - Metabolites
PLK4_HUMAN
GeneCards
O00444
DOCK Blaster
4N7Z
,
4N9J
,
5LHY
,
5LHZ
,
4YYP
,
4N7V
,
4YUR
,
4JXF
,
3COK
BRENDA (Homo sapiens)
2.7.11.21
Orphanet
23133
ZINC - Predictions - Purchasable
PLK4_HUMAN
HMDB Protein
HMDBP01289
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.675
4
UniProt:P39009
2
phospho-p-T68-CHEK2 [nucleoplasm]
(R-SCE-113825)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(R-SCE-5683784)
0.556
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.508
2
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.488
2
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