Reactome | PLK4 [cytosol]

PLK4 [cytosol]

Stable Identifier

R-HSA-380286

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PLK4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00444 PLK4

Gene Names

PLK4, SAK, STK18

Chain

chain:1-970

Reference Genes

BioGPS Gene:10733 PLK4

COSMIC (genes):PLK4 PLK4

CTD Gene:10733 PLK4

dbSNP Gene:10733 PLK4

ENSEMBL:ENSG00000142731 PLK4

ENSEMBL_homo_sapiens_GENE:ENSG00000142731.11 PLK4

HGNC:11397 PLK4

KEGG Gene (Homo sapiens):10733 PLK4

Monarch:10733 PLK4

NCBI Gene:10733 PLK4

OMIM:605031 PLK4

UCSC:O00444 PLK4

Reference Transcript

Other Identifiers

10733

11732242_a_at

11747114_a_at

16970563

204886_PM_at

204886_at

204887_PM_s_at

204887_s_at

211088_PM_s_at

211088_s_at

2742984

2742986

2742987

2742988

2742993

2742994

2742997

2742998

2743000

2743001

2743002

2743003

2743004

2743005

2743007

2743008

2743009

2743010

2743012

2743013

2743014

2743015

2743016

2743017

2743018

2743019

2743020

2743021

2743022

32703_at

4068436

8097356

82748_at

975_at

A_14_P105267

A_14_P125392

A_23_P155969

A_24_P912925

GE60304

GO:0000166

GO:0001741

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0007010

GO:0007099

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0030154

GO:0032154

GO:0036211

GO:0042802

GO:0043226

GO:0044782

GO:0046601

GO:0048856

GO:0060271

GO:0060707

GO:0098535

GO:0098536

GO:0106310

GO:0120098

GO:0120099

GO:0140096

HMNXSV003044615

ILMN_1789123

PH_hs_0010304

TC04000645.hg

Y13115_at

g405744_3p_s_at

g7657626_3p_a_at

Participates

as a component of

Inferred To

PLK4 [cytosol] (Bos taurus)

PLK4 [cytosol] (Canis familiaris)

PLK4 [cytosol] (Mus musculus)

PLK4 [cytosol] (Rattus norvegicus)

PLK4 [cytosol] (Sus scrofa)

PLK4 [cytosol] (Xenopus tropicalis)

Ghost homologue of PLK4 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001177730.1, NP_055079.3, NP_001177728.1

ZINC - World Drugs

PLK4_HUMAN

Guide to Pharmacology - Targets

2171

OpenTargets

ENSG00000142731

ZINC - FDA approved

PLK4_HUMAN

ZINC - Substances

PLK4_HUMAN

ZINC - Biogenic

PLK4_HUMAN

ZINC target

O00444

PRO

O00444

PDB

3COK, 6N45, 4YUR, 8XPG, 4N7V, 6W3I, 4N7Z, 6W3J, 6W38, 5LHY, 4JXF, 4N9J, 4YYP, 6N46, 5LHZ, 2N19

ZINC - Investigational

PLK4_HUMAN

ZINC - Metabolites

PLK4_HUMAN

HPA

ENSG00000142731-PLK4

GeneCards

O00444

Ensembl

ENSG00000142731, ENST00000270861, ENST00000514379, ENSP00000270861, ENSP00000427554, ENST00000513090, ENSP00000423582

Pharos - Targets

O00444

Orphanet

23133

ZINC - Predictions - Purchasable

PLK4_HUMAN

HMDB Protein

HMDBP01289

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.675	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.646	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3

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