Reactome | PLK4 [cytosol]

PLK4 [cytosol]

Stable Identifier

R-BTA-380286

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

A2VDZ4

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Bos taurus)

- Cilium Assembly (Bos taurus)
  - Anchoring of the basal body to the plasma membrane (Bos taurus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - C2CD3 binds the mother centriole (Bos taurus)
      - mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - CP110 and CEP97 dissociate from the centriole (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - MARK4 binds ODF2 in the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - Recruitment of transition zone proteins (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
    - The distal appendage proteins recruit TTBK2 (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        PLK4 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A2VDZ4

Reference Genes

BioGPS Gene:514405

ENSEMBL:ENSBTAG00000039552

ENSEMBL:ENSBTAG00000039552.3

KEGG Gene (Bos taurus):514405

Monarch:514405

NCBI Gene:514405

Reference Transcript

RefSeq:NM_001083427.2

Other Identifiers

514405

GO:0003824

GO:0004672

GO:0005515

GO:0005524

GO:0006468

GO:0016740

GO:0036211

GO:0140096

Participates

as a component of

Inferred From

PLK4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001076896.1

Ensembl

ENSBTAT00000055868, ENSBTAG00000039552, ENSBTAP00000048808

VGNC

33036

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