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Class A/1 (Rhodopsin-like receptors)
Stable Identifier
R-HSA-373076
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
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Rhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and thus, can be subdivided into 19 subfamilies (Subfamily A1-19) based on a phylogenetic analysis (Joost P and Methner A, 2002). They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes.
Literature References
PubMed ID
Title
Journal
Year
16902930
The 7 TM G-protein-coupled receptor target family
Bouhelal, R
,
Jacoby, E
,
Gerspacher, M
,
Seuwen, K
ChemMedChem
2006
Participants
Events
Peptide ligand-binding receptors
(Homo sapiens)
Amine ligand-binding receptors
(Homo sapiens)
Hormone ligand-binding receptors
(Homo sapiens)
Eicosanoid ligand-binding receptors
(Homo sapiens)
Nucleotide-like (purinergic) receptors
(Homo sapiens)
Hydroxycarboxylic acid-binding receptors
(Homo sapiens)
Cannabinoid receptors can bind cannabinoids
(Homo sapiens)
CNRs bind CNR agonists
(Homo sapiens)
PAF receptor binds platelet activating factor
(Homo sapiens)
Melatonin receptors can bind melatonin
(Homo sapiens)
Lysosphingolipid and LPA receptors
(Homo sapiens)
Opsins
(Homo sapiens)
Free fatty acid receptors
(Homo sapiens)
GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
(Homo sapiens)
HCAR2 binds HCAR2 ligands
(Homo sapiens)
G-protein coupled bile acid receptor binds lithocholic acid
(Homo sapiens)
N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine
(Homo sapiens)
Zinc is an agonist of GPR39
(Homo sapiens)
OXGR1 binds 2OG
(Homo sapiens)
SUCNR1 binds SUCCA
(Homo sapiens)
GPR35 binds kynurenic acid
(Homo sapiens)
GPR183 binds 7alpha,25-dihydroxycholesterol
(Homo sapiens)
CMKLR1 binds Resolvin E1
(Homo sapiens)
Participates
as an event of
GPCR ligand binding (Homo sapiens)
Event Information
Go Biological Process
G protein-coupled receptor signaling pathway (0007186)
Orthologous Events
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Dictyostelium discoideum)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Saccharomyces cerevisiae)
Class A/1 (Rhodopsin-like receptors) (Schizosaccharomyces pombe)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Authored
Jassal, B (2008-07-03)
Reviewed
Bockaert, J (2008-09-01)
Created
Jassal, B (2008-07-14)
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