Reactome | Trace amine-associated receptors can bind trace amines

Trace amine-associated receptors can bind trace amines

Stable Identifier

R-HSA-391211

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Trace amine-associated receptors can bind trace amines

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Trace amines, such as para-tyramine, beta-phenylethylamine (beta-PEA) and tryptamine are endogenous sympathomimetics. They are related to classical biogenic amines such as histamine, serotonin and catecholamines. The trace amine receptor TAR1 was identified in rat (Borowsky et al. 2001; Bunzow et al. 2001) and recognized to be a member of a family of trace amine-associated receptors (TAARs). Humans have seven subtypes plus a number of pseudogenes (TAAR1,2,3,5,6,8 and 9). Only one of these has been demonstrated to respond to trace amines, TAAR1. These receptors mediate their actions by coupling with the G protein alpha-s subtype, which activates adenylate cyclase and elevates cellular cAMP levels. Beta-PEA is the trace amine used as an example in this annotation.

Literature References

PubMed ID	Title	Journal	Year
11459929	Trace amines: identification of a family of mammalian G protein-coupled receptors Borowsky, B, Adham, N, Jones, KA, Raddatz, R, Artymyshyn, R, Ogozalek, KL, Durkin, MM, Lakhlani, PP, Bonini, JA, Pathirana, S, Boyle, N, Pu, X, Kouranova, E, Lichtblau, H, Ochoa, FY, Branchek, TA, Gerald, C	Proc Natl Acad Sci U S A	2001
17218486	Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine Reese, EA, Bunzow, JR, Arttamangkul, S, Sonders, MS, Grandy, DK	J Pharmacol Exp Ther	2007