Trace amine-associated receptors can bind trace amines

Stable Identifier
Reaction [binding]
Homo sapiens
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Trace amines, such as para-tyramine, beta-phenylethylamine (beta-PEA) and tryptamine are endogenous sympathomimetics. They are related to classical biogenic amines such as histamine, serotonin and catecholamines. The trace amine receptor TAR1 was identified in rat (Borowsky et al. 2001; Bunzow et al. 2001) and recognized to be a member of a family of trace amine-associated receptors (TAARs). Humans have seven subtypes plus a number of pseudogenes (TAAR1,2,3,5,6,8 and 9). Only one of these has been demonstrated to respond to trace amines, TAAR1. These receptors mediate their actions by coupling with the G protein alpha-s subtype, which activates adenylate cyclase and elevates cellular cAMP levels. Beta-PEA is the trace amine used as an example in this annotation.

Literature References
PubMed ID Title Journal Year
11459929 Trace amines: identification of a family of mammalian G protein-coupled receptors

Lichtblau, H, Bonini, JA, Jones, KA, Branchek, TA, Borowsky, B, Pu, X, Artymyshyn, R, Boyle, N, Pathirana, S, Ochoa, FY, Gerald, C, Ogozalek, KL, Kouranova, E, Raddatz, R, Adham, N, Durkin, MM, Lakhlani, PP

Proc Natl Acad Sci U S A 2001
17218486 Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine

Reese, EA, Sonders, MS, Arttamangkul, S, Bunzow, JR, Grandy, DK

J Pharmacol Exp Ther 2007
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