Reactome | Adrenoceptors

Adrenoceptors

Stable Identifier

R-HSA-390696

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The adrenoceptors (adrenergic receptors) are targets for the catecholamines adrenaline (epinephrine) and noradrenaline (norepinephrine). These receptors are widespread in the body and binding of catecholamines produces a sympathetic response ('flight-or-fight response') resulting in increased heart rate, pupil dilation and energy mobilization amongst other responses. There are three major types of adrenoceptor, alpha1, alpha2 and beta. Each type is thought to have three subtypes; alpha1 (1A,1B,1D), alpha2 (2A,2B,2C) and beta (1,2,3) (Bylund DB et al, 1994).

Literature References

PubMed ID	Title	Journal	Year
7938162	International Union of Pharmacology nomenclature of adrenoceptors Bylund, DB, Eikenberg, DC, Hieble, JP, Langer, SZ, Lefkowitz, RJ, Minneman, KP, Molinoff, PB, Ruffolo RR, Jr, Trendelenburg, U	Pharmacol Rev	1994