IL34 dimer binds PTPRZ1

Stable Identifier
R-HSA-8981657
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL34 dimer binds PTPRZ1
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Interleukin-34 (IL34) signals via the Colony-stimulating factor-1 receptor (CSF1R). It can also bind Receptor-type protein-tyrosine phosphatase zeta (PTPRZ1), a cell surface chondroitin sulfate (CS) proteoglycan. PTPRZ1 is primarily expressed on neural progenitor and glial cells. IL34 selectively bound PTPRZ1 in CSF1R-deficient U251 human glioblastoma cell lysates, inhibiting proliferation, clonogenicity and motility, and promoting an increase in tyrosine phosphorylation of focal adhesion kinase 1 (PTK2) and paxillin (PXN) (Nandii et al. 2013).
Literature References
PubMed ID Title Journal Year
23744080 Receptor-type protein-tyrosine phosphatase ΞΆ is a functional receptor for interleukin-34

Cioce, M, Hsu, AW, Stanley, ER, Mehler, MF, Nandi, S, Gokhan, S, Cheng, HY, Halenbeck, R, Tesfa, L, Nieves, E, Lin, H, Yeung, YG

J. Biol. Chem. 2013
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Orthologous Events
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IL34 dimer binds PTPRZ1 (Sus scrofa)
Authored
Jupe, S  (2017-03-13)
Reviewed
Meldal, BH  (2017-11-03)
Created
Jupe, S  (2017-03-13)
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