IL34 dimer binds PTPRZ1

Stable Identifier
R-HSA-8981657
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL34 dimer binds PTPRZ1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Interleukin-34 (IL34) signals via the Colony-stimulating factor-1 receptor (CSF1R). It can also bind Receptor-type protein-tyrosine phosphatase zeta (PTPRZ1), a cell surface chondroitin sulfate (CS) proteoglycan. PTPRZ1 is primarily expressed on neural progenitor and glial cells. IL34 selectively bound PTPRZ1 in CSF1R-deficient U251 human glioblastoma cell lysates, inhibiting proliferation, clonogenicity and motility, and promoting an increase in tyrosine phosphorylation of focal adhesion kinase 1 (PTK2) and paxillin (PXN) (Nandii et al. 2013).
Literature References
PubMed ID Title Journal Year
23744080 Receptor-type protein-tyrosine phosphatase ΞΆ is a functional receptor for interleukin-34

Nandi, S, Cioce, M, Yeung, YG, Nieves, E, Tesfa, L, Lin, H, Hsu, AW, Halenbeck, R, Cheng, HY, Gokhan, S, Mehler, MF, Stanley, ER

J. Biol. Chem. 2013
Participants
Input
Output
Participates
as an event of
Orthologous Events
IL34 dimer binds PTPRZ1 (Bos taurus)
IL34 dimer binds PTPRZ1 (Canis familiaris)
IL34 dimer binds PTPRZ1 (Gallus gallus)
IL34 dimer binds PTPRZ1 (Mus musculus)
IL34 dimer binds PTPRZ1 (Rattus norvegicus)
IL34 dimer binds PTPRZ1 (Sus scrofa)
Authored
Jupe, S  (2017-03-13)
Reviewed
Meldal, BH  (2017-11-03)
Created
Jupe, S  (2017-03-13)
Cite Us!