Reactome | GATAD2A [nucleoplasm]

GATAD2A [nucleoplasm]

Stable Identifier

R-HSA-3702077

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional repressor p66-alpha, P66A_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - Potential therapeutics for SARS (Homo sapiens)
      - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86YP4 GATAD2A

Gene Names

GATAD2A

Chain

chain:1-633

Reference Genes

BioGPS Gene:54815 GATAD2A

COSMIC (genes):GATAD2A GATAD2A

CTD Gene:54815 GATAD2A

dbSNP Gene:54815 GATAD2A

ENSEMBL:ENSG00000167491.18 GATAD2A

HGNC:29989 GATAD2A

KEGG Gene (Homo sapiens):54815 GATAD2A

Monarch:54815 GATAD2A

NCBI Gene:54815 GATAD2A

OMIM:614997 GATAD2A

UCSC:Q86YP4 GATAD2A

Reference Transcript

Other Identifiers

0002120288

11719644_a_at

11719645_a_at

11746871_a_at

11754716_s_at

16860017

218131_PM_s_at

218131_s_at

222526_PM_at

222526_at

234294_PM_x_at

234294_x_at

238324_PM_at

238324_at

3825715

3825716

3825717

3825718

3825719

3825720

3825721

3825730

3825731

3825735

3825745

3825746

3825747

3825748

3825749

3825750

3825751

3825752

3825755

3825757

3825759

3825760

3825761

3825762

3825763

3825764

3825765

3825766

3825767

3825768

3825769

3825770

3825774

3825776

3825787

48898_at

48899_at

54815

65991_at

78378_at

8027169

A_14_P103677

A_14_P118391

A_14_P118620

A_14_P124223

A_23_P131020

A_24_P305467

GE82200

GO:0000122

GO:0003677

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006306

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016575

GO:0016581

GO:0016607

GO:0030154

GO:0030674

GO:0032991

GO:0036211

GO:0042659

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0046872

GO:0060090

GO:2000736

HMNXSV003015155

Hs.118964.0.A2_3p_at

Hs.40178.1.S1_3p_at

Hs.40178.1.S1_3p_x_at

ILMN_1673682

PH_hs_0006564

TC19000373.hg

g8923093_3p_a_at

Participates

as a candidate of

(GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)

Inferred To

GATAD2A [nucleoplasm] (Bos taurus)

GATAD2A [nucleoplasm] (Canis familiaris)

GATAD2A [nucleoplasm] (Danio rerio)

GATAD2A [nucleoplasm] (Gallus gallus)

GATAD2A [nucleoplasm] (Sus scrofa)

dcp-66 [nucleoplasm] (Caenorhabditis elegans)

Gatad2a [nucleoplasm] (Mus musculus)

Gatad2a [nucleoplasm] (Rattus norvegicus)

gatad2a [nucleoplasm] (Xenopus tropicalis)

simj [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001287875.1, XP_011526407.1, NP_060130.3

OpenTargets

ENSG00000167491

HPA

ENSG00000167491-GATAD2A

GeneCards

Q86YP4

Ensembl

ENST00000358713, ENSG00000167491, ENST00000360315, ENSP00000384899, ENST00000404158, ENSP00000508398, ENST00000683918, ENSP00000351552, ENSP00000353463

PRO

Q86YP4

Pharos - Targets

Q86YP4

PDB

2L2L

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.837	8
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	4
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.643	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	2

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