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TNKS1/2 [cytosol]
Stable Identifier
R-HSA-3640826
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
XAV939 stabilizes AXIN (Homo sapiens)
XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS1/2:XAV939 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
TNKS and TNKS2 PARylate PTEN (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Tankyrase ADP-ribosylates AXIN (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Tankyrase binds AXIN (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
Participants
members
TNKS2 [cytosol]
(Homo sapiens)
TNKS [cytosol]
(Homo sapiens)
Participates
as a component of
TNKS1/2:XAV939 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
as an input of
XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)
Tankyrase binds AXIN (Homo sapiens)
as an output of
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
Inferred To
TNKS [cytosol]
(Sus scrofa)
TNKS1/2 [cytosol]
(Bos taurus)
TNKS1/2 [cytosol]
(Canis familiaris)
TNKS1/2 [cytosol]
(Gallus gallus)
TNKS1/2 [cytosol]
(Mus musculus)
TNKS1/2 [cytosol]
(Rattus norvegicus)
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