SMAD1:SMAD4 trimer binds ZNF423

Stable Identifier
R-HSA-9844425
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD1:SMAD4 trimer binds ZNF423
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Based on studies in mice, bone morphogenic protein BMP7, known as the brown fat determination factor, stimulates formation of an active SMAD heterotrimer composed of two molecules of phosphorylated SMAD1 and one molecule of SMAD4 that binds to ZNF423 transcription factor. Binding of ZNF423 to the BMP7-induced complex of SMAD1 and SMAD4 interferes with association of ZNF423 with the EBF2 transcription factor (inferred from mouse homologs in Shao et al. 2016).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BMP7 dimer [extracellular region] (Homo sapiens)
Active Unit
BMP7 dimer [extracellular region]
Inferred From
Smad1:Smad4 trimer binds Znf423 (Mus musculus)
Authored
Orlic-Milacic, M  (2023-09-25)
Reviewed
Chun, TH  (2023-11-29)
Created
Orlic-Milacic, M  (2023-09-16)
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