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ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423
Stable Identifier
R-HSA-9844818
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423 (Homo sapiens)
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ELOVL3 gene encodes elongation of very long chain fatty acids protein 3, an endoplasmic reticulum membrane enzyme involved in the elongation of long-chain fatty acids in brown adipocytes. ELOVL3 gene expression is positively regulated by the EBF2 cofactor Blnc1 lncRNA (mouse and human study Mi et al. 2017) and dependent on the EBF2-binding subunit of the BAF chromatin remodeling complex SMARCD1 (BAF60A) (mouse study Liu et al. 2020). ELOVL3 gene expression is negatively regulated by the EBF2 inhibitor ZNF423 (mouse study Shao et al. 2016). As direct binding of EBF2 to the regulatory sequences of ELOVL3 gene has not been reported, ELOVL3 is annotated as a candidate EBF2 target gene.
Participants
Input
ELOVL3 gene [nucleoplasm]
(Homo sapiens)
Output
ELOVL3 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
This event is regulated
Negatively by
Regulator
ZNF423 [nucleoplasm]
(Homo sapiens)
Active Unit
ZNF423 [nucleoplasm]
Positively by
Regulator
EBF2,EBF2:Blnc1 lncRNA:HNRNPU [nucleoplasm]
(Homo sapiens)
Active Unit
EBF2,EBF2:Blnc1 lncRNA:HNRNPU [nucleoplasm]
Inferred From
Elovl3 gene expression is positively regulated by Ebf2 and negatively regulated by Znf423 (Mus musculus)
Authored
Orlic-Milacic, M (2023-09-25)
Reviewed
Chun, TH (2023-11-29)
Created
Orlic-Milacic, M (2023-09-22)
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