ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423

Stable Identifier
R-HSA-9844818
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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ELOVL3 gene encodes elongation of very long chain fatty acids protein 3, an endoplasmic reticulum membrane enzyme involved in the elongation of long-chain fatty acids in brown adipocytes. ELOVL3 gene expression is positively regulated by the EBF2 cofactor Blnc1 lncRNA (mouse and human study Mi et al. 2017) and dependent on the EBF2-binding subunit of the BAF chromatin remodeling complex SMARCD1 (BAF60A) (mouse study Liu et al. 2020). ELOVL3 gene expression is negatively regulated by the EBF2 inhibitor ZNF423 (mouse study Shao et al. 2016). As direct binding of EBF2 to the regulatory sequences of ELOVL3 gene has not been reported, ELOVL3 is annotated as a candidate EBF2 target gene.
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