Reactome | TP53 stimulates PLK3 expression

TP53 stimulates PLK3 expression

Stable Identifier

R-HSA-6802170

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 stimulates PLK3 expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the promoter of the PLK3 gene stimulates PLK3 transcription (Jen and Cheung 2005).

Literature References

PubMed ID	Title	Journal	Year
16140933	Identification of novel p53 target genes in ionizing radiation response Jen, KY, Cheung, VG	Cancer Res.	2005

Participants

Input

PLK3 Gene [nucleoplasm] (Homo sapiens)

Output

PLK3 [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

This event is regulated

Positively by

Regulator

p-S15,S20-TP53 Tetramer:PLK3 Gene [nucleoplasm] (Homo sapiens)

Active Unit

p-S15,S20-TP53 Tetramer [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-02)

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