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DNAJC6 [cytosol]
Stable Identifier
R-HSA-264472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Putative tyrosine-protein phosphatase auxilin, AUXI_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
HSC70:Auxillin Complex [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
Lysosome Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
HSC70:Auxillin Complex [cytosol] (Homo sapiens)
DNAJC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75061 DNAJC6
Gene Names
DNAJC6, KIAA0473
Chain
chain:1-913
Reference Genes
BioGPS Gene:9829 DNAJC6
COSMIC (genes):DNAJC6 DNAJC6
CTD Gene:9829 DNAJC6
dbSNP Gene:9829 DNAJC6
ENSEMBL:ENSG00000116675 DNAJC6
HGNC:15469 DNAJC6
KEGG Gene (Homo sapiens):9829 DNAJC6
Monarch:9829 DNAJC6
NCBI Gene:9829 DNAJC6
OMIM:608375 DNAJC6
UCSC:O75061 DNAJC6
Reference Transcript
RefSeq:NM_014787.3 DNAJC6
RefSeq:NM_001256865.1 DNAJC6
RefSeq:NM_001256864.1 DNAJC6
Other Identifiers
0001850148
0103440253
11745300_a_at
11745301_a_at
11745939_a_at
16665687
204720_s_at
204721_s_at
2340357
2340361
2340362
2340363
2340364
2340365
2340375
2340376
2340377
2340378
2340379
2340381
2340384
2340385
2340386
2340387
2340388
2340389
2340390
2340391
2340392
2340393
2340394
2340395
2340396
2340398
2340399
2340401
2340402
2340403
2340404
2340405
2340406
31182
36022_at
54917
7902043
9829
A_14_P125278
A_14_P133959
A_23_P147479
A_23_P95359
A_33_P3216714
AAH51722
AAI09280
AAI09281
AB007942
AC119800
AK296408
AL139294
AL355487
AL356212
BAA32318
BAH12344
BC051722
BC109279
BC109280
CCDS30739
CCDS58004
CCDS58005
CH471059
DNAJC6
DNAJC6-201
DNAJC6-202
DNAJC6-203
EAX06533
EAX06534
EAX06536
EAX06537
ENSG00000116675
ENSP00000263441
ENSP00000360108
ENSP00000378735
ENST00000263441
ENST00000263441.11
ENST00000371069
ENST00000371069.4
ENST00000395325
ENST00000395325.7
EntrezGene:9829
EntrezGene:DNAJC6
g7662145_3p_a_at
GE53207
GO:0003674
GO:0004721
GO:0004725
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0006810
GO:0006898
GO:0008150
GO:0014069
GO:0016191
GO:0016192
GO:0016787
GO:0016791
GO:0017124
GO:0030276
GO:0031982
GO:0035335
GO:0043226
GO:0043231
GO:0045202
GO:0061024
GO:0072318
GO:0072583
GO:0098793
GO:2000369
HGNC:15469
HPA031182
HPA054917
Hs.44896.0.S1_3p_a_at
ILMN_1696079
ILMN_2166543
IPR001623
IPR014020
IPR029021
IPR029023
IPR036869
MIM:608375
MIM:615528
NM_001256864
NM_001256865
NM_014787
NP_001243793
NP_001243794
NP_055602
PF00226
PF10409
PH_hs_0003254
S4R305
SM00271
SM01326
TC01000729.hg
UPI000007355D
UPI00002044F7
UPI000022AE8A
Participant Of
hasMember
GAK,DNAJC6 [cytosol]
hasComponent
HSC70:Auxillin Complex [cytosol]
Inferred To
DNAJC6 [cytosol] (Caenorhabditis elegans)
DNAJC6 [cytosol] (Canis familiaris)
DNAJC6 [cytosol] (Danio rerio)
DNAJC6 [cytosol] (Dictyostelium discoideum)
DNAJC6 [cytosol] (Drosophila melanogaster)
DNAJC6 [cytosol] (Gallus gallus)
DNAJC6 [cytosol] (Mus musculus)
DNAJC6 [cytosol] (Plasmodium falciparum)
DNAJC6 [cytosol] (Rattus norvegicus)
DNAJC6 [cytosol] (Saccharomyces cerevisiae)
DNAJC6 [cytosol] (Schizosaccharomyces pombe)
DNAJC6 [cytosol] (Sus scrofa)
DNAJC6 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001243793.1
,
NP_055602.1
,
NP_001243794.1
OpenTargets
ENSG00000116675
IntEnz
3.1.3.48
GeneCards
O75061
PRO
O75061
Orphanet
22171
HMDB Protein
HMDBP08897
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