Reactome | Dnajc6 [cytosol]

Dnajc6 [cytosol]

Stable Identifier

R-MMU-264472

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DNAJC6, Q80TZ3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        GAK,DNAJC6 [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
  - trans-Golgi Network Vesicle Budding (Mus musculus)
    - Golgi Associated Vesicle Biogenesis (Mus musculus)
      - trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)
        
        HSC70:Auxillin Complex [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)
    - Lysosome Vesicle Biogenesis (Mus musculus)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)
        
        HSC70:Auxillin Complex [cytosol] (Mus musculus)
        
        Dnajc6 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q80TZ3

Gene Names

Dnajc6

Reference Genes

BioGPS Gene:72685 Dnajc6

ENSEMBL:ENSMUSG00000028528

Monarch:72685 Dnajc6

NCBI Gene:72685 Dnajc6

UCSC:Q80TZ3 Dnajc6

Reference Transcript

Other Identifiers

10506274

1431216_s_at

1433596_at

17415943

4330917

4472848

4512024

4603342

4666175

4692427

4705511

4734102

4742769

4744806

4761037

4834048

4857273

4893837

4973645

4993751

5098494

5122255

5130647

5144340

5150801

5174352

5228910

5240408

5256610

5310604

5357236

5375729

5401924

5421283

5518810

5567364

5575875

72685

A_51_P431885

A_55_P2146304

GE39696

GO:0003824

GO:0004721

GO:0004725

GO:0005737

GO:0014069

GO:0016191

GO:0016192

GO:0016311

GO:0016787

GO:0017124

GO:0030136

GO:0030276

GO:0031072

GO:0031410

GO:0031982

GO:0032050

GO:0036465

GO:0043226

GO:0043231

GO:0045202

GO:0046907

GO:0072318

GO:0072583

GO:0098894

GO:0140096

GO:1905443

GO:2000369

ILMN_1230224

ILMN_1242127

ILMN_1256627

ILMN_2733605

mMC010315

mMC025192

mMR027078

Participates

as a member of

GAK,DNAJC6 [cytosol] (Mus musculus)

as a component of

HSC70:Auxillin Complex [cytosol] (Mus musculus)

Inferred From

DNAJC6 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUST00000106930, ENSMUST00000094953, ENSMUSP00000044251, ENSMUST00000106929, ENSMUSP00000102546, ENSMUST00000038207, ENSMUSP00000102542, ENSMUSP00000102543, ENSMUST00000106933, ENSMUSP00000092560

PRO

Q80TZ3

GlyGen

Q80TZ3

MGI

1919935

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