Reactome | DNAJC6 [cytosol]

DNAJC6 [cytosol]

Stable Identifier

R-CFA-264472

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

DNAJC6, A0A8I3Q052

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        GAK,DNAJC6 [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
  - trans-Golgi Network Vesicle Budding (Canis familiaris)
    - Golgi Associated Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)
        
        HSC70:Auxillin Complex [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)
    - Lysosome Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)
        
        HSC70:Auxillin Complex [cytosol] (Canis familiaris)
        
        DNAJC6 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q052

Gene Names

DNAJC6

Reference Genes

BioGPS Gene:489553 DNAJC6

ENSEMBL:ENSCAFG00845029438.1

Monarch:489553 DNAJC6

NCBI Gene:489553 DNAJC6

UCSC:A0A8I3Q052 DNAJC6

Reference Transcript

Other Identifiers

489553

CfaAffx.28436.1.S1_at

GO:0003824

GO:0004721

GO:0005737

GO:0014069

GO:0016191

GO:0016192

GO:0016311

GO:0016787

GO:0017124

GO:0030136

GO:0030276

GO:0031410

GO:0031982

GO:0036465

GO:0043226

GO:0045202

GO:0072318

GO:0072583

GO:0098894

GO:0140096

GO:1905443

GO:2000369

Participates

as a component of

HSC70:Auxillin Complex [cytosol] (Canis familiaris)

as a member of

GAK,DNAJC6 [cytosol] (Canis familiaris)

Inferred From

DNAJC6 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038393158.1, XP_546673.2, XP_038521852.1

ENSEMBL

ENSCAFG00845029438, ENSCAFT00845052119, ENSCAFP00845040880

Cite Us!