Reactome | RDH5 oxidises 11cROL to 11cRAL

RDH5 oxidises 11cROL to 11cRAL

Stable Identifier

R-HSA-2454081

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

RDH5 oxidises 11-cis-retinol to 11-cis-retinal

ReviewStatus

5/5

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Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.

Literature References

PubMed ID	Title	Journal	Year
8884265	Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene Simon, A, Lagercrantz, J, Bajalica-Lagercrantz, S, Eriksson, U	Genomics	1996
10617778	11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus Conway, BP, Kurz, D, Khani, SC, Gonzalez-Fernandez, F, Young, JE, Newman, S, Bao, Y, Han, DP	Mol. Vis.	1999