Metabolism of ingested H2SeO4 and H2SeO3 into H2Se

Stable Identifier
R-HSA-2408550
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
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Ingested selenic acid (H2SeO4) and selenite (SeO3(2-)) are reduced to hydrogen selenide (H2Se) through a combination of actions involving bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 and 2 (PAPSS1/2), PAPSe reductase (PAPSeR), and thioredoxin reductase 1 (TXNRD1).

Literature References
PubMed ID Title Journal Year
19406206 Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase

Lu, J, Berndt, C, Holmgren, A

Biochim. Biophys. Acta 2009
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Event Information
Go Biological Process
selenium compound metabolic process (0001887)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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