GSSeSG is reduced to GSSeH and GSH by GSR

Stable Identifier
R-HSA-2408542
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)
ReviewStatus
5/5
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GSSeSG is reduced to GSSeH and GSH by GSR
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Glutathione reductase (GSR) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH). This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
Literature References
PubMed ID Title Journal Year
1569062 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

Björnstedt, M, Kumar, S, Holmgren, A

J. Biol. Chem. 1992
Participants
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Output
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as an event of
Catalyst Activity

selenodiglutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]

Physical Entity
GSR-2:FAD dimer [cytosol] (Homo sapiens)
Activity
selenodiglutathione-disulfide reductase (NADPH) activity (GO:0098622)
Inferred From
GSSeSG is reduced to GSSeH and GSH by Gsr (Rattus norvegicus)
Cross References
RHEA
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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