SeO3(2-) combines with GSH to form GSSeSG and GSSG

Stable Identifier
R-HSA-2408556
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SeO3(2-) combines with GSH to form GSSeSG and GSSG
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Selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism. This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
Literature References
PubMed ID Title Journal Year
1569062 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

Björnstedt, M, Holmgren, A, Kumar, S

J. Biol. Chem. 1992
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Inferred From
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Rattus norvegicus)
Cross References
Rhea
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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