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FYN,LCK [cytosol]
Stable Identifier
R-HSA-2395419
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
FYN,LCK [cytosol] (Homo sapiens)
Participants
members
FYN [cytosol]
(Homo sapiens)
LCK [cytosol]
(Homo sapiens)
Participates
as an input of
Phosphorylation of CD28 (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
as a component of
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
Inferred To
FYN [cytosol]
(Xenopus tropicalis)
FYN,LCK [cytosol]
(Bos taurus)
FYN,LCK [cytosol]
(Canis familiaris)
FYN,LCK [cytosol]
(Gallus gallus)
FYN,LCK [cytosol]
(Mus musculus)
FYN,LCK [cytosol]
(Rattus norvegicus)
FYN,LCK [cytosol]
(Sus scrofa)
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