Phosphorylation of CD28

Stable Identifier
Homo sapiens
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The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.

Literature References
PubMed ID Title Journal Year
9973466 Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells

Truitt, KE, Imboden, JB, Cinek, T, Arellano, JL, Shi, J, Sadra, A

J Immunol 1999
8946678 Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion

August, A, Selvakumar, A, Dupont, B, King, PD, Liu, X, Sadra, A, Han, A, Teng, JM

Tissue Antigens 1996
Catalyst Activity

protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]

Orthologous Events
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