Phosphorylation of CD28

Stable Identifier
R-HSA-388831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of CD28
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The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.

Literature References
PubMed ID Title Journal Year
8946678 Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion

Teng, JM, King, PD, Sadra, A, Liu, X, Han, A, Selvakumar, A, August, A, Dupont, B

Tissue Antigens 1996
9973466 Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells

Sadra, A, Cinek, T, Arellano, JL, Shi, J, Truitt, KE, Imboden, JB

J Immunol 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]
Physical Entity
Src family tyrosine kinases (SFKs) [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of CD28 (Canis familiaris)
Phosphorylation of CD28 (Mus musculus)
Phosphorylation of CD28 (Rattus norvegicus)
Phosphorylation of CD28 (Sus scrofa)
Phosphorylation of CD28 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)