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Phosphorylation of DAP12
Stable Identifier
R-HSA-2395439
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
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Crosslinking of receptors associated with DAP12 leads to phosphorylation of tyrosine residues in their cytoplasmic ITAM by SRC family kinases (Turnbull & Colonna 2007). This initiates downstream signaling. FYN and LCK have both been found physically and functionally associated with receptors using DAP12 signaling and have been demonstrated to be involved in DAP12 phosphorylation (Mason et al. 2006).
Participants
Input
x 4
ATP [cytosol]
DAP12 receptors:DAP12 dimer [plasma membrane]
(Homo sapiens)
FYN,LCK [cytosol]
(Homo sapiens)
Output
x 4
ADP [cytosol]
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane]
(Homo sapiens)
Participates
as an event of
DAP12 signaling (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of FYN,LCK [cytosol]
Physical Entity
FYN,LCK [cytosol]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of DAP12 (Mus musculus)
Authored
Garapati, P V (2012-05-25)
Reviewed
Lanier, LL (2012-08-09)
Created
Garapati, P V (2012-06-29)
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