Phosphorylation of DAP12

Stable Identifier
R-HSA-2395439
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Crosslinking of receptors associated with DAP12 leads to phosphorylation of tyrosine residues in their cytoplasmic ITAM by SRC family kinases (Turnbull & Colonna 2007). This initiates downstream signaling. FYN and LCK have both been found physically and functionally associated with receptors using DAP12 signaling and have been demonstrated to be involved in DAP12 phosphorylation (Mason et al. 2006).

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of FYN,LCK [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created