Homodimerization of DFF40

Stable Identifier
R-HSA-211193
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Following its release from DFF45, DFF40 forms homodimers, which are the basic structures of the enzymatically active nuclease (Woo et al., 2004). Following dimerization, DFF40 can further oligomerize forming units containing at least 4 monomers (Liu et al., 1999; Widlak et al., 2003).

Literature References
PubMed ID Title Journal Year
15149602 Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway

Woo, EJ, Kim, YG, Kim, MS, Han, WD, Shin, S, Robinson, H, Park, SY, Oh, BH

Mol Cell 2004
10318789 Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

Liu, X, Zou, H, Widlak, P, Garrard, W, Wang, X

J Biol Chem 1999
12748178 Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis

Widlak, P, Lanuszewska, J, Cary, RB, Garrard, WT

J Biol Chem 2003
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