Reactome | Homodimerization of DFF40

Homodimerization of DFF40

Stable Identifier

R-HSA-211193

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Following its release from DFF45, DFF40 forms homodimers, which are the basic structures of the enzymatically active nuclease (Woo et al., 2004). Following dimerization, DFF40 can further oligomerize forming units containing at least 4 monomers (Liu et al., 1999; Widlak et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
10318789	Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1 Liu, X, Zou, H, Widlak, P, Garrard, W, Wang, X	J Biol Chem	1999
15149602	Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway Woo, EJ, Kim, YG, Kim, MS, Han, WD, Shin, S, Robinson, H, Park, SY, Oh, BH	Mol Cell	2004
12748178	Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis Widlak, P, Lanuszewska, J, Cary, RB, Garrard, WT	J Biol Chem	2003