Iodothyronine deiodinases 1 and 2 (DIO1/2) are the vertebrate enzymes responsible for the deiodination of the prohormone thyroxine (T4; 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine). DIO1/2 activity is critical for appropriate T3 levels in the brain during development.
Berry, MJ, Mandel, SJ, Larsen, PR, Warne, RL, Harney, JW, Kieffer, JD
thyroxine 5'-deiodinase activity of DIO dimer [plasma membrane]
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