Thyroxine is deiodinated to triiodothyronine

Stable Identifier
R-HSA-209772
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Iodothyronine deiodinases 1 and 2 (DIO1/2) are the vertebrate enzymes responsible for the deiodination of the prohormone thyroxine (T4; 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine). DIO1/2 activity is critical for appropriate T3 levels in the brain during development.

Literature References
PubMed ID Title Journal Year
1400883 Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase

Mandel, SJ, Berry, MJ, Kieffer, JD, Harney, JW, Warne, RL, Larsen, PR

J Clin Endocrinol Metab 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thyroxine 5'-deiodinase activity of DIO dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created