Reactome | Thyroxine is deiodinated to triiodothyronine

Thyroxine is deiodinated to triiodothyronine

Stable Identifier

R-HSA-209772

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Thyroxine is deiodinated to triiodothyronine

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Iodothyronine deiodinases 1 and 2 (DIO1/2) are the vertebrate enzymes responsible for the deiodination of the prohormone thyroxine (T4; 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine). DIO1/2 activity is critical for appropriate T3 levels in the brain during development.

Literature References

PubMed ID	Title	Journal	Year
1400883	Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase Mandel, SJ, Berry, MJ, Kieffer, JD, Harney, JW, Warne, RL, Larsen, PR	J Clin Endocrinol Metab	1992