Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HS(2)-HSPG2 [plasma membrane]
Stable Identifier
R-HSA-2076659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HSPG2, Perlecan
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-HSPG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98160 HSPG2
Gene Names
HSPG2
Chain
signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391
Reference Genes
COSMIC (genes):HSPG2 HSPG2
dbSNP Gene:3339 HSPG2
ENSEMBL:ENSG00000142798 HSPG2
Participates
as a member of
HS(2)-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
HSPG2(22-4196) [extracellular region]
HS(4)-HSPG2 [plasma membrane]
HS(6)-HSPG2 [plasma membrane]
HS(1)-HSPG2 [plasma membrane]
HS(3)-HSPG2 [plasma membrane]
HS(5)-HSPG2 [plasma membrane]
HSPG2(3687-4391) [extracellular region]
XylS-HSPG2(22-4391) [Golgi lumen]
Gal-Xyl-HSPG2 [Golgi lumen]
HSPG2(22-4391) [Golgi lumen]
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
HS(3)-HSPG2 [Golgi lumen]
HS(4)-HSPG2 [Golgi lumen]
HS(2)-HSPG2 [Golgi lumen]
HS(1)-HSPG2 [Golgi lumen]
Heparan(4)-HSPG2 [Golgi lumen]
Heparan(3)-HSPG2 [Golgi lumen]
Heparan(2)-HSPG2 [Golgi lumen]
Heparan(1)-HSPG2 [Golgi lumen]
Heparan-HSPG2 [Golgi lumen]
HS(5)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [lysosomal lumen]
HSPG2(22-4391) [lysosomal lumen]
HSPG2(22-4391) [extracellular region]
Heparan sulfate-HSPG2 [extracellular region]
HSPG2(?-4391) [extracellular region]
HSPG2(22-?) [extracellular region]
HSPG2(4197-4391) [extracellular region]
Inferred To
fipi [plasma membrane]
(Drosophila melanogaster)
CT35293 [plasma membrane]
(Drosophila melanogaster)
DIP-delta [plasma membrane]
(Drosophila melanogaster)
DIP-lambda [plasma membrane]
(Drosophila melanogaster)
Homologues of HS(2)-HSPG2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of HS(2)-HSPG2 [plasma membrane]
(Drosophila melanogaster)
DIP-eta [plasma membrane]
(Drosophila melanogaster)
DIP-gamma [plasma membrane]
(Drosophila melanogaster)
DIP-beta [plasma membrane]
(Drosophila melanogaster)
DIP-kappa [plasma membrane]
(Drosophila melanogaster)
HS(2)-HSPG2 [plasma membrane]
(Caenorhabditis elegans)
CT35363 [plasma membrane]
(Drosophila melanogaster)
Lac [plasma membrane]
(Drosophila melanogaster)
DIP-zeta [plasma membrane]
(Drosophila melanogaster)
DIP-theta [plasma membrane]
(Drosophila melanogaster)
DIP-epsilon [plasma membrane]
(Drosophila melanogaster)
rig-5 [plasma membrane]
(Caenorhabditis elegans)
DIP-alpha [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63653) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.719
5
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.564
3
ChEBI:28304 HEPARIN
0.564
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.53
3
UniProt:Q9H9D4 ZN408
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text