Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
Stable Identifier
R-HSA-2063971
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
HSPG2, Perlecan
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B3GAT3 causes JDSSDHD (Homo sapiens)
Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Gal-Xyl-HSPG2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98160 HSPG2
Gene Names
HSPG2
Chain
signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391
Reference Genes
COSMIC (genes):HSPG2 HSPG2
dbSNP Gene:3339 HSPG2
ENSEMBL:ENSG00000142798 HSPG2
Participates
as a member of
Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HSPG2(22-4196) [extracellular region]
HS(4)-HSPG2 [plasma membrane]
HS(6)-HSPG2 [plasma membrane]
HS(2)-HSPG2 [plasma membrane]
HS(1)-HSPG2 [plasma membrane]
HS(3)-HSPG2 [plasma membrane]
HS(5)-HSPG2 [plasma membrane]
HSPG2(3687-4391) [extracellular region]
XylS-HSPG2(22-4391) [Golgi lumen]
Gal-Xyl-HSPG2 [Golgi lumen]
HSPG2(22-4391) [Golgi lumen]
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
HS(3)-HSPG2 [Golgi lumen]
HS(4)-HSPG2 [Golgi lumen]
HS(2)-HSPG2 [Golgi lumen]
HS(1)-HSPG2 [Golgi lumen]
Heparan(4)-HSPG2 [Golgi lumen]
Heparan(3)-HSPG2 [Golgi lumen]
Heparan(2)-HSPG2 [Golgi lumen]
Heparan(1)-HSPG2 [Golgi lumen]
Heparan-HSPG2 [Golgi lumen]
HS(5)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [lysosomal lumen]
HSPG2(22-4391) [lysosomal lumen]
HSPG2(22-4391) [extracellular region]
Heparan sulfate-HSPG2 [extracellular region]
HSPG2(?-4391) [extracellular region]
HSPG2(22-?) [extracellular region]
HSPG2(4197-4391) [extracellular region]
Inferred To
DIP-beta [Golgi lumen]
(Drosophila melanogaster)
CT35293 [Golgi lumen]
(Drosophila melanogaster)
CT35363 [Golgi lumen]
(Drosophila melanogaster)
DIP-eta [Golgi lumen]
(Drosophila melanogaster)
DIP-lambda [Golgi lumen]
(Drosophila melanogaster)
DIP-kappa [Golgi lumen]
(Drosophila melanogaster)
fipi [Golgi lumen]
(Drosophila melanogaster)
Lac [Golgi lumen]
(Drosophila melanogaster)
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
DIP-gamma [Golgi lumen]
(Drosophila melanogaster)
DIP-alpha [Golgi lumen]
(Drosophila melanogaster)
rig-5 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(Drosophila melanogaster)
DIP-theta [Golgi lumen]
(Drosophila melanogaster)
DIP-delta [Golgi lumen]
(Drosophila melanogaster)
DIP-epsilon [Golgi lumen]
(Drosophila melanogaster)
DIP-zeta [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63503) at unknown position
Modification
beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.719
5
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.564
3
ChEBI:28304 HEPARIN
0.564
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.53
3
UniProt:Q9H9D4 ZN408
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text