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Heparan-HSPG2 [Golgi lumen]
Stable Identifier
R-HSA-2076367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GlcA-Gal-Gal-Xyl-HSPG2, Perlecan
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-HSPG2 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-HSPG2 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-HSPG2 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-HSPG2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98160 HSPG2
Gene Names
HSPG2
Chain
signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391
Reference Genes
COSMIC (genes):HSPG2 HSPG2
dbSNP Gene:3339 HSPG2
ENSEMBL:ENSG00000142798 HSPG2
Participates
as a member of
Heparan-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HSPG2(22-4196) [extracellular region]
HS(4)-HSPG2 [plasma membrane]
HS(6)-HSPG2 [plasma membrane]
HS(2)-HSPG2 [plasma membrane]
HS(1)-HSPG2 [plasma membrane]
HS(3)-HSPG2 [plasma membrane]
HS(5)-HSPG2 [plasma membrane]
HSPG2(3687-4391) [extracellular region]
XylS-HSPG2(22-4391) [Golgi lumen]
Gal-Xyl-HSPG2 [Golgi lumen]
HSPG2(22-4391) [Golgi lumen]
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
HS(3)-HSPG2 [Golgi lumen]
HS(4)-HSPG2 [Golgi lumen]
HS(2)-HSPG2 [Golgi lumen]
HS(1)-HSPG2 [Golgi lumen]
Heparan(4)-HSPG2 [Golgi lumen]
Heparan(3)-HSPG2 [Golgi lumen]
Heparan(2)-HSPG2 [Golgi lumen]
Heparan(1)-HSPG2 [Golgi lumen]
HS(5)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [lysosomal lumen]
HSPG2(22-4391) [lysosomal lumen]
HSPG2(22-4391) [extracellular region]
Heparan sulfate-HSPG2 [extracellular region]
HSPG2(?-4391) [extracellular region]
HSPG2(22-?) [extracellular region]
HSPG2(4197-4391) [extracellular region]
Inferred To
Homologues of Heparan-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of Heparan-HSPG2 [Golgi lumen]
(Drosophila melanogaster)
DIP-beta [Golgi lumen]
(Drosophila melanogaster)
Heparan-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
CT35293 [Golgi lumen]
(Drosophila melanogaster)
CT35363 [Golgi lumen]
(Drosophila melanogaster)
DIP-eta [Golgi lumen]
(Drosophila melanogaster)
DIP-lambda [Golgi lumen]
(Drosophila melanogaster)
DIP-kappa [Golgi lumen]
(Drosophila melanogaster)
fipi [Golgi lumen]
(Drosophila melanogaster)
Lac [Golgi lumen]
(Drosophila melanogaster)
DIP-gamma [Golgi lumen]
(Drosophila melanogaster)
DIP-alpha [Golgi lumen]
(Drosophila melanogaster)
rig-5 [Golgi lumen]
(Caenorhabditis elegans)
DIP-theta [Golgi lumen]
(Drosophila melanogaster)
DIP-delta [Golgi lumen]
(Drosophila melanogaster)
DIP-epsilon [Golgi lumen]
(Drosophila melanogaster)
DIP-zeta [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63645) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.719
5
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.564
3
ChEBI:28304 HEPARIN
0.564
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.53
3
UniProt:Q9H9D4 ZN408
0.527
2
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