Reactome | DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A

DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A

Stable Identifier

R-HSA-204617

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine

ReviewStatus

5/5

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DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A

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Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes the reaction of the deoxyhypusine (Dhp) residue in EIF5A protein (Dhp-K50-EIF5A) with 1,3 diaminopropane, NADH and H+ to form EIF5A, spermidine (SPM), and NAD+ (Park et al. 2003; Park 2006). While this reaction is readily observed in vitro, it is probably minimized by the rapid, irreversible conversion of EIF5A Dhp residues to hypusine.

Literature References

PubMed ID	Title	Journal	Year
12788913	Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase Folk, JE, Wolff, EC, Park, MH, Park, JH	J. Biol. Chem.	2003
16452303	The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A) Park, MH	J Biochem (Tokyo)	2006