DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A

Stable Identifier
R-HSA-204617
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine
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Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes the reaction of the deoxyhypusine (Dhp) residue in EIF5A protein (Dhp-K50-EIF5A) with 1,3 diaminopropane, NADH and H+ to form EIF5A, spermidine (SPM), and NAD+ (Park et al. 2003; Park 2006). While this reaction is readily observed in vitro, it is probably minimized by the rapid, irreversible conversion of EIF5A Dhp residues to hypusine.

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Event Information
Catalyst Activity
Catalyst Activity
Title
deoxyhypusine synthase activity of DHPS tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
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