MIA2 and MIA3 load procollagen VII into COPII vesicles

Stable Identifier
Reaction [binding]
Homo sapiens
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MIA2 (also known as CTAGE5) and MIA3 form heterodimers through their second coiled coil domains and interact with inner coat proteins SEC24C and SEC23A through their proline-rich domains. In this way, the MIA3 and MIA2 concentrate procollagen VII at ER exit sites (Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References
PubMed ID Title Journal Year
25619253 Procollagen export from the endoplasmic reticulum

Malhotra, V, Erlmann, P, Nogueira, C

Biochem. Soc. Trans. 2015
21878990 Protein export at the ER: loading big collagens into COPII carriers

Malhotra, V, Erlmann, P

EMBO J 2011
21525241 cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites

Saito, K, Yamashiro, K, Ichikawa, Y, Erlmann, P, Kontani, K, Malhotra, V, Katada, T

Mol. Biol. Cell 2011
Participant Of
Orthologous Events
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