Reactome | MIA2 and MIA3 load procollagen VII into COPII vesicles

MIA2 and MIA3 load procollagen VII into COPII vesicles

Stable Identifier

R-HSA-5694435

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)

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MIA2 and MIA3 load procollagen VII into COPII vesicles

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MIA2 (also known as CTAGE5) and MIA3 form heterodimers through their second coiled coil domains and interact with inner coat proteins SEC24C and SEC23A through their proline-rich domains. In this way, the MIA3 and MIA2 concentrate procollagen VII at ER exit sites (Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
21878990	Protein export at the ER: loading big collagens into COPII carriers Malhotra, V, Erlmann, P	EMBO J	2011
25619253	Procollagen export from the endoplasmic reticulum Erlmann, P, Nogueira, C, Malhotra, V	Biochem. Soc. Trans.	2015
21525241	cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites Erlmann, P, Saito, K, Yamashiro, K, Katada, T, Malhotra, V, Kontani, K, Ichikawa, Y	Mol. Biol. Cell	2011