Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
palmitoylated, myristoylated eNOS dimer [plasma membrane]
Stable Identifier
R-HSA-203639
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS activation (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Depalmitoylation of eNOS (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS associates with Caveolin-1 (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS translocation from Golgi to Caveolae (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8995432
Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.
Venema, VJ
,
Ryan, JW
,
Zou, R
,
Ju, H
,
Venema, RC
J Biol Chem
1997
Participants
components
x 2
2xPalmC-MyrG-NOS3 [plasma membrane]
(Homo sapiens)
x 2
FAD [cytosol]
x 2
ferroheme [cytosol]
x 2
FMN [cytosol]
Zn2+ [cytosol]
Participates
as an input of
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Homo sapiens)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
Depalmitoylation of eNOS (Homo sapiens)
eNOS associates with Caveolin-1 (Homo sapiens)
as a component of
eNOS:NOSIP [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
as an output of
eNOS translocation from Golgi to Caveolae (Homo sapiens)
Inferred To
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Saccharomyces cerevisiae)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Sus scrofa)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text