Depalmitoylation of eNOS

Stable Identifier
R-HSA-203613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
H2O + S-hexadecanoyl-L-cysteinyl-(protein) => H(+) + hexadecanoate + L-cysteinyl-(protein)
ReviewStatus
5/5
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Depalmitoylation of eNOS
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Increases in intracellular calcium and calmodulin stimulate depalmitoylation of eNOS by acyl protein thioesterase 1, which displaces eNOS from the membrane. This might be a mechanism to downregulate NO production following intense stimuli.
Literature References
PubMed ID Title Journal Year
10551886 Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin

Yeh, DC, Duncan, JA, Yamashita, S, Michel, T

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

palmitoyl-(protein) hydrolase activity of LYPLA1 dimer [cytosol]

Physical Entity
LYPLA1 dimer [cytosol] (Homo sapiens)
Activity
palmitoyl-(protein) hydrolase activity (GO:0008474)
Orthologous Events
Depalmitoylation of eNOS (Bos taurus)
Depalmitoylation of eNOS (Dictyostelium discoideum)
Depalmitoylation of eNOS (Drosophila melanogaster)
Depalmitoylation of eNOS (Mus musculus)
Depalmitoylation of eNOS (Rattus norvegicus)
Depalmitoylation of eNOS (Saccharomyces cerevisiae)
Depalmitoylation of eNOS (Schizosaccharomyces pombe)
Depalmitoylation of eNOS (Sus scrofa)
Cross References
RHEA
Authored
Hemish, J  (2007-10-19)
Reviewed
Enikolopov, G  (2008-02-28)
Hill, DP  (2024-08-02)
Created
Hemish, J  (2007-10-19)
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