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What is Reactome ?
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Table of Contents
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FAD [cytosol]
Stable Identifier
R-ALL-29386
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
FAD(3-), Flavin adenine dinucleotide
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 complex [phagocytic vesicle membrane] (Bos taurus)
Cytochrome b-245 [phagocytic vesicle membrane] (Bos taurus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
XDH oxidises 6MP to 6TU (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)
NQO2:FAD dimer [cytosol] (Bos taurus)
NQO2:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Methylation (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Cholesterol biosynthesis (Bos taurus)
Squalene is oxidized to its epoxide (Bos taurus)
SQLE:FAD [endoplasmic reticulum membrane] (Bos taurus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
NOSIP mediated eNOS trafficking (Bos taurus)
eNOS binds NOSIP (Bos taurus)
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
eNOS:NOSIP [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Bos taurus)
FAD [cytosol]
depalmitoylation of eNOS (Bos taurus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
Pyrimidine catabolism (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
FAD [cytosol]
FLAD1 phosphorylates FMN (Bos taurus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
AOX1 oxidises PXL to PDXate (Bos taurus)
2xAOX1:cofactors [cytosol] (Bos taurus)
AOX1:cofactors [cytosol] (Bos taurus)
FAD [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 binds effectors at the plasma membrane (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Hemostasis (Caenorhabditis elegans)
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)
MICAL1:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
FAD [cytosol]
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
2xAOX1:cofactors [cytosol] (Caenorhabditis elegans)
AOX1:cofactors [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
Cytochrome b-245 [phagocytic vesicle membrane] (Canis familiaris)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)
TNXRD1:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
XDH oxidises 6MP to 6TU (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)
TNXRD1:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Hemostasis (Canis familiaris)
Factors involved in megakaryocyte development and platelet production (Canis familiaris)
MICAL1 produces NADP+, H2O2 (Canis familiaris)
MICAL1:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)
NQO2:FAD dimer [cytosol] (Canis familiaris)
NQO2:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested MeSeO2H into MeSeH (Canis familiaris)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Canis familiaris)
TNXRD1:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Canis familiaris)
TNXRD1:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Cholesterol biosynthesis (Canis familiaris)
Squalene is oxidized to its epoxide (Canis familiaris)
SQLE:FAD [endoplasmic reticulum membrane] (Canis familiaris)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSIP mediated eNOS trafficking (Canis familiaris)
eNOS binds NOSIP (Canis familiaris)
eNOS:NOSIP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Canis familiaris)
eNOS:NOSIP [Golgi membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Canis familiaris)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS activation (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Canis familiaris)
myristoylated eNOS dimer [Golgi membrane] (Canis familiaris)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Canis familiaris)
FAD [cytosol]
eNOS associates with Caveolin-1 (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)
TNXRD1:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Pyrimidine catabolism (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
FAD [cytosol]
FLAD1 phosphorylates FMN (Canis familiaris)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)
FAD [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Canis familiaris)
eNOS:Caveolin-1 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 complex [phagocytic vesicle membrane] (Danio rerio)
Cytochrome b-245 [phagocytic vesicle membrane] (Danio rerio)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)
GSR-2:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)
TNXRD1:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Drug ADME (Danio rerio)
Azathioprine ADME (Danio rerio)
XDH oxidises 6MP to 6TU (Danio rerio)
XDH dimer [cytosol] (Danio rerio)
FAD [cytosol]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)
GSR-2:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)
TNXRD1:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Hemostasis (Danio rerio)
Factors involved in megakaryocyte development and platelet production (Danio rerio)
MICAL1 produces NADP+, H2O2 (Danio rerio)
MICAL1:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
NQO2:FAD dimer reduces quinones to hydroquinones (Danio rerio)
NQO2:FAD dimer [cytosol] (Danio rerio)
NQO2:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Methylation (Danio rerio)
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR:MeCbl [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Selenoamino acid metabolism (Danio rerio)
Metabolism of ingested MeSeO2H into MeSeH (Danio rerio)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Danio rerio)
TNXRD1:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Danio rerio)
TNXRD1:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Sulfur amino acid metabolism (Danio rerio)
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR:MeCbl [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Cholesterol biosynthesis (Danio rerio)
Squalene is oxidized to its epoxide (Danio rerio)
SQLE:FAD [endoplasmic reticulum membrane] (Danio rerio)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS activation (Danio rerio)
AKT1 phosphorylates eNOS (Danio rerio)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
eNOS:CaM:HSP90 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS synthesizes NO (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)
GSR-2:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)
TNXRD1:FAD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
XDH dehydrogenates hypoxanthine to form xanthine (Danio rerio)
XDH dimer [cytosol] (Danio rerio)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Danio rerio)
XDH dimer [cytosol] (Danio rerio)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Danio rerio)
XDH dimer [cytosol] (Danio rerio)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Danio rerio)
XDH dimer [cytosol] (Danio rerio)
FAD [cytosol]
Pyrimidine catabolism (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
BH2 binding can lead to eNOS uncoupling (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Danio rerio)
Cobalamin (Cbl) metabolism (Danio rerio)
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR:MeCbl [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Danio rerio)
MTRR:MTR:MeCbl [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTRR:FMN:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
FAD [cytosol]
FLAD1 phosphorylates FMN (Danio rerio)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Danio rerio)
AOX1 oxidises PXL to PDXate (Danio rerio)
2xAOX1:cofactors [cytosol] (Danio rerio)
AOX1:cofactors [cytosol] (Danio rerio)
FAD [cytosol]
Signal Transduction (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
eNOS synthesizes NO (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Danio rerio)
AKT1 phosphorylates eNOS (Danio rerio)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
eNOS:CaM:HSP90 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS synthesizes NO (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
p-S1177-eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate NADPH Oxidases (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
RHO GTPase cycle (Danio rerio)
RAC1 GTPase cycle (Danio rerio)
RAC1 binds effectors at the plasma membrane (Danio rerio)
RAC1 effectors [cytosol] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Danio rerio)
RAC1 effectors [cytosol] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
RAC3 GTPase cycle (Danio rerio)
RAC3 binds effectors at the plasma membrane (Danio rerio)
RAC3 effectors [cytosol] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Danio rerio)
RAC3 effectors [cytosol] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Hemostasis (Dictyostelium discoideum)
Factors involved in megakaryocyte development and platelet production (Dictyostelium discoideum)
MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
MICAL1:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Methylation (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Metabolism of steroids (Dictyostelium discoideum)
Cholesterol biosynthesis (Dictyostelium discoideum)
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
SQLE:FAD [endoplasmic reticulum membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
FAD [cytosol]
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
2xAOX1:cofactors [cytosol] (Dictyostelium discoideum)
AOX1:cofactors [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)
TNXRD1:FAD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Drug ADME (Drosophila melanogaster)
Azathioprine ADME (Drosophila melanogaster)
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)
TNXRD1:FAD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Selenoamino acid metabolism (Drosophila melanogaster)
Metabolism of ingested MeSeO2H into MeSeH (Drosophila melanogaster)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Drosophila melanogaster)
TNXRD1:FAD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Drosophila melanogaster)
TNXRD1:FAD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
NOSIP mediated eNOS trafficking (Drosophila melanogaster)
eNOS binds NOSIP (Drosophila melanogaster)
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
eNOS:NOSIP [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Drosophila melanogaster)
NOSTRIN mediated translocation of eNOS from plasma membrane (Drosophila melanogaster)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Drosophila melanogaster)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Drosophila melanogaster)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS activation (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
depalmitoylation of eNOS (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)
TNXRD1:FAD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Vitamin B2 (riboflavin) metabolism (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
2xAOX1:cofactors [cytosol] (Drosophila melanogaster)
AOX1:cofactors [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex [phagocytic vesicle membrane] (Gallus gallus)
Cytochrome b-245 [phagocytic vesicle membrane] (Gallus gallus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
XDH oxidises 6MP to 6TU (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Hemostasis (Gallus gallus)
Factors involved in megakaryocyte development and platelet production (Gallus gallus)
MICAL1 produces NADP+, H2O2 (Gallus gallus)
MICAL1:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
NQO2:FAD dimer reduces quinones to hydroquinones (Gallus gallus)
NQO2:FAD dimer [cytosol] (Gallus gallus)
NQO2:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Methylation (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Cholesterol biosynthesis (Gallus gallus)
Squalene is oxidized to its epoxide (Gallus gallus)
SQLE:FAD [endoplasmic reticulum membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
NOSTRIN mediated eNOS trafficking (Gallus gallus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Gallus gallus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS activation (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FAD [cytosol]
depalmitoylation of eNOS (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Pyrimidine catabolism (Gallus gallus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
FLAD1 phosphorylates FMN (Gallus gallus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Gallus gallus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Gallus gallus)
AOX1 oxidises PXL to PDXate (Gallus gallus)
2xAOX1:cofactors [cytosol] (Gallus gallus)
AOX1:cofactors [cytosol] (Gallus gallus)
FAD [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]