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About
What is Reactome ?
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Team
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Release Calendar
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License Agreement
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Digital Preservation
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Table of Contents
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FAD [cytosol]
Stable Identifier
R-ALL-29386
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
FAD(3-), Flavin adenine dinucleotide
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Bos taurus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Bos taurus)
p-S633-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Bos taurus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 complex [phagocytic vesicle membrane] (Bos taurus)
Cytochrome b-245 [phagocytic vesicle membrane] (Bos taurus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
XDH oxidises 6MP to 6TU (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)
NQO2:FAD dimer [cytosol] (Bos taurus)
NQO2:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Methylation (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Cholesterol biosynthesis (Bos taurus)
Squalene is oxidized to its epoxide (Bos taurus)
SQLE:FAD [endoplasmic reticulum membrane] (Bos taurus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
NOSIP mediated eNOS trafficking (Bos taurus)
eNOS binds NOSIP (Bos taurus)
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
eNOS:NOSIP [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Depalmitoylation of eNOS (Bos taurus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Bos taurus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
GSR-2:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Bos taurus)
XDH dimer [cytosol] (Bos taurus)
FAD [cytosol]
Pyrimidine catabolism (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
FAD [cytosol]
FLAD1 phosphorylates FMN (Bos taurus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
AOX1 oxidises PXL to PDXate (Bos taurus)
2xAOX1:cofactors [cytosol] (Bos taurus)
AOX1:cofactors [cytosol] (Bos taurus)
FAD [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 binds effectors at the plasma membrane (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
FAD [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Hemostasis (Caenorhabditis elegans)
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)
MICAL1:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
XDH dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
FAD [cytosol]
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
2xAOX1:cofactors [cytosol] (Caenorhabditis elegans)
AOX1:cofactors [cytosol] (Caenorhabditis elegans)
FAD [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FAD [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
Cytochrome b-245 [phagocytic vesicle membrane] (Canis familiaris)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
XDH oxidises 6MP to 6TU (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)
NQO2:FAD dimer [cytosol] (Canis familiaris)
NQO2:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Sulfur amino acid metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Cholesterol biosynthesis (Canis familiaris)
Squalene is oxidized to its epoxide (Canis familiaris)
SQLE:FAD [endoplasmic reticulum membrane] (Canis familiaris)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FAD [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Canis familiaris)
XDH dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Pyrimidine catabolism (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FAD [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
FAD [cytosol]
FLAD1 phosphorylates FMN (Canis familiaris)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)
FAD [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RAC3 GTPase cycle (Canis familiaris)
RAC3 binds effectors at the plasma membrane (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
FAD [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 complex [phagocytic vesicle membrane] (Danio rerio)
Cytochrome b-245 [phagocytic vesicle membrane] (Danio rerio)
FAD [cytosol]
Hemostasis (Danio rerio)
Factors involved in megakaryocyte development and platelet production (Danio rerio)
MICAL1 produces NADP+, H2O2 (Danio rerio)
MICAL1:FAD [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Cholesterol biosynthesis (Danio rerio)
Squalene is oxidized to its epoxide (Danio rerio)
SQLE:FAD [endoplasmic reticulum membrane] (Danio rerio)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FAD [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Pyrimidine catabolism (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FAD [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
FAD [cytosol]
FLAD1 phosphorylates FMN (Danio rerio)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Danio rerio)
AOX1 oxidises PXL to PDXate (Danio rerio)
2xAOX1:cofactors [cytosol] (Danio rerio)
AOX1:cofactors [cytosol] (Danio rerio)
FAD [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate NADPH Oxidases (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
FAD [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to mechanical stimuli (Dictyostelium discoideum)
Response of endothelial cells to shear stress (Dictyostelium discoideum)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Dictyostelium discoideum)
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Dictyostelium discoideum)
p-S1177,S1179-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Hemostasis (Dictyostelium discoideum)
Factors involved in megakaryocyte development and platelet production (Dictyostelium discoideum)
MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
MICAL1:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Methylation (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Metabolism of steroids (Dictyostelium discoideum)
Cholesterol biosynthesis (Dictyostelium discoideum)
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
SQLE:FAD [endoplasmic reticulum membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
XDH dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
FAD [cytosol]
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
2xAOX1:cofactors [cytosol] (Dictyostelium discoideum)
AOX1:cofactors [cytosol] (Dictyostelium discoideum)
FAD [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FAD [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Drosophila melanogaster)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Drosophila melanogaster)
p-S633-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Drosophila melanogaster)
p-S1177,S1179-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Drug ADME (Drosophila melanogaster)
Azathioprine ADME (Drosophila melanogaster)
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
NOSIP mediated eNOS trafficking (Drosophila melanogaster)
eNOS binds NOSIP (Drosophila melanogaster)
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
eNOS:NOSIP [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS activation (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Depalmitoylation of eNOS (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Drosophila melanogaster)
XDH dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Vitamin B2 (riboflavin) metabolism (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
2xAOX1:cofactors [cytosol] (Drosophila melanogaster)
AOX1:cofactors [cytosol] (Drosophila melanogaster)
FAD [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FAD [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to mechanical stimuli (Gallus gallus)
Response of endothelial cells to shear stress (Gallus gallus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Gallus gallus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Gallus gallus)
p-S633-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Gallus gallus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex [phagocytic vesicle membrane] (Gallus gallus)
Cytochrome b-245 [phagocytic vesicle membrane] (Gallus gallus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
XDH oxidises 6MP to 6TU (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Hemostasis (Gallus gallus)
Factors involved in megakaryocyte development and platelet production (Gallus gallus)
MICAL1 produces NADP+, H2O2 (Gallus gallus)
MICAL1:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
NQO2:FAD dimer reduces quinones to hydroquinones (Gallus gallus)
NQO2:FAD dimer [cytosol] (Gallus gallus)
NQO2:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Methylation (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Cholesterol biosynthesis (Gallus gallus)
Squalene is oxidized to its epoxide (Gallus gallus)
SQLE:FAD [endoplasmic reticulum membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
NOSTRIN mediated eNOS trafficking (Gallus gallus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Gallus gallus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS activation (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Depalmitoylation of eNOS (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Gallus gallus)
XDH dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Pyrimidine catabolism (Gallus gallus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
FLAD1 phosphorylates FMN (Gallus gallus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Gallus gallus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Gallus gallus)
AOX1 oxidises PXL to PDXate (Gallus gallus)
2xAOX1:cofactors [cytosol] (Gallus gallus)
AOX1:cofactors [cytosol] (Gallus gallus)
FAD [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate NADPH Oxidases (Gallus gallus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
RHO GTPase cycle (Gallus gallus)
RAC1 GTPase cycle (Gallus gallus)
RAC1 binds effectors at the plasma membrane (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
RAC3 GTPase cycle (Gallus gallus)
RAC3 binds effectors at the plasma membrane (Gallus gallus)
RAC3 effectors [cytosol] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Gallus gallus)
RAC3 effectors [cytosol] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
FAD [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Homo sapiens)
p-S633-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Homo sapiens)
p-S1177,S1179-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
Cytochrome b-245 [phagocytic vesicle membrane] (Homo sapiens)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)
NQO1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
NFE2L2-dependent GSR gene expression (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective MTR causes HMAG (Homo sapiens)
Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)
MTRR:mutant MTR(cob(I)alamin) [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)
MTRR:mutant MTR(MeCbl) [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Defective MTRR causes HMAE (Homo sapiens)
Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)
mutant MTRR:MTR(cob(II)alamin) [cytosol] (Homo sapiens)
mutant MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Cell redox homeostasis (Homo sapiens)
LpdC dimer reactivates DlaT (Homo sapiens)
LpdC dimer [cytosol] (Mycobacterium tuberculosis)
FAD [cytosol]
TrxB reactivates TrxA (Homo sapiens)
TrxB dimer [cytosol] (Mycobacterium tuberculosis)
FAD [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
XDH oxidises 6MP to 6TU (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
MICAL1 produces NADP+, H2O2 (Homo sapiens)
MICAL1:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)
NQO2:FAD dimer [cytosol] (Homo sapiens)
NQO2:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Phase II - Conjugation of compounds (Homo sapiens)
Methylation (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Cytosolic iron-sulfur cluster assembly (Homo sapiens)
4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)
NDOR1:CIAPIN1 reduced [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FAD [cytosol]
NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)
NDOR1:CIAPIN1 oxidized [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FAD [cytosol]
NDOR1:CIAPIN1 reduced [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FAD [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
Squalene is oxidized to its epoxide (Homo sapiens)
SQLE:FAD [endoplasmic reticulum membrane] (Homo sapiens)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
eNOS:NOSIP [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS activation (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Depalmitoylation of eNOS (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Homo sapiens)
FAD [cytosol]
eNOS associates with Caveolin-1 (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Pyrimidine catabolism (Homo sapiens)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
DPYD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
DPYD dimer [cytosol] (Homo sapiens)
FAD [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
FAD [cytosol]
FLAD1 phosphorylates FMN (Homo sapiens)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Homo sapiens)
AOX1 oxidises PXL to PDXate (Homo sapiens)
2xAOX1:cofactors [cytosol] (Homo sapiens)
AOX1:cofactors [cytosol] (Homo sapiens)
FAD [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
FAD [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Mus musculus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Mus musculus)
p-S633-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Mus musculus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
NOX2 generates superoxide from oxygen (Mus musculus)
NOX2 complex [phagocytic vesicle membrane] (Mus musculus)
Cytochrome b-245 [phagocytic vesicle membrane] (Mus musculus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
GSR-2:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
XDH oxidises 6MP to 6TU (Mus musculus)
XDH dimer [cytosol] (Mus musculus)
FAD [cytosol]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
GSR-2:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)
NQO2:FAD dimer [cytosol] (Mus musculus)
NQO2:FAD [cytosol] (Mus musculus)
FAD [cytosol]
Phase II - Conjugation of compounds (Mus musculus)
Methylation (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Selenoamino acid metabolism (Mus musculus)
Metabolism of ingested MeSeO2H into MeSeH (Mus musculus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
Sulfur amino acid metabolism (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Cholesterol biosynthesis (Mus musculus)
Squalene is oxidized to its epoxide (Mus musculus)
SQLE:FAD [endoplasmic reticulum membrane] (Mus musculus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
NOSIP mediated eNOS trafficking (Mus musculus)
eNOS binds NOSIP (Mus musculus)
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)
eNOS:NOSIP [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Mus musculus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Mus musculus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS activation (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Mus musculus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Depalmitoylation of eNOS (Mus musculus)
myristoylated eNOS dimer [cytosol] (Mus musculus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Mus musculus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
GSR-2:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
FAD [cytosol]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
XDH dimer [cytosol] (Mus musculus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Mus musculus)
XDH dimer [cytosol] (Mus musculus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Mus musculus)
XDH dimer [cytosol] (Mus musculus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Mus musculus)
XDH dimer [cytosol] (Mus musculus)
FAD [cytosol]
Pyrimidine catabolism (Mus musculus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
DPYD dimer [cytosol] (Mus musculus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
DPYD dimer [cytosol] (Mus musculus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
FAD [cytosol]
FLAD1 phosphorylates FMN (Mus musculus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Mus musculus)
AOX1 oxidises PXL to PDXate (Mus musculus)
2xAOX1:cofactors [cytosol] (Mus musculus)
AOX1:cofactors [cytosol] (Mus musculus)
FAD [cytosol]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Mus musculus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate NADPH Oxidases (Mus musculus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 binds effectors at the plasma membrane (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
RAC3 GTPase cycle (Mus musculus)
RAC3 binds effectors at the plasma membrane (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
FAD [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
Cellular response to chemical stress (Plasmodium falciparum)
Detoxification of Reactive Oxygen Species (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
GSR-2:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
Gene expression (Transcription) (Plasmodium falciparum)
RNA Polymerase II Transcription (Plasmodium falciparum)
Generic Transcription Pathway (Plasmodium falciparum)
Transcriptional Regulation by TP53 (Plasmodium falciparum)
TP53 Regulates Metabolic Genes (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
GSR-2:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Selenoamino acid metabolism (Plasmodium falciparum)
Metabolism of ingested MeSeO2H into MeSeH (Plasmodium falciparum)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Plasmodium falciparum)
NOSIP mediated eNOS trafficking (Plasmodium falciparum)
eNOS binds NOSIP (Plasmodium falciparum)
eNOS:NOSIP [plasma membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)
eNOS:NOSIP [Golgi membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
eNOS activation (Plasmodium falciparum)
AKT1 phosphorylates eNOS (Plasmodium falciparum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
eNOS:CaM:HSP90 [plasma membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)
myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
GSR-2:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
FAD [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of cofactors (Plasmodium falciparum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Plasmodium falciparum)
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Vitamin B2 (riboflavin) metabolism (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Plasmodium falciparum)
FAD [cytosol]
Signal Transduction (Plasmodium falciparum)
Signaling by Nuclear Receptors (Plasmodium falciparum)
ESR-mediated signaling (Plasmodium falciparum)
Extra-nuclear estrogen signaling (Plasmodium falciparum)
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by VEGF (Plasmodium falciparum)
VEGFA-VEGFR2 Pathway (Plasmodium falciparum)
VEGFR2 mediated vascular permeability (Plasmodium falciparum)
AKT1 phosphorylates eNOS (Plasmodium falciparum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
eNOS:CaM:HSP90 [plasma membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
FAD [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Rattus norvegicus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Rattus norvegicus)
p-S633-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Rattus norvegicus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 complex [phagocytic vesicle membrane] (Rattus norvegicus)
Cytochrome b-245 [phagocytic vesicle membrane] (Rattus norvegicus)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
GSR-2:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
XDH oxidises 6MP to 6TU (Rattus norvegicus)
XDH dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
GSR-2:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)
NQO2:FAD dimer [cytosol] (Rattus norvegicus)
NQO2:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
Phase II - Conjugation of compounds (Rattus norvegicus)
Methylation (Rattus norvegicus)
MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)
MTRR:MTR:MeCbl [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Selenoamino acid metabolism (Rattus norvegicus)
Metabolism of ingested MeSeO2H into MeSeH (Rattus norvegicus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)
MTRR:MTR:MeCbl [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Cholesterol biosynthesis (Rattus norvegicus)
Squalene is oxidized to its epoxide (Rattus norvegicus)
SQLE:FAD [endoplasmic reticulum membrane] (Rattus norvegicus)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
NOSIP mediated eNOS trafficking (Rattus norvegicus)
eNOS binds NOSIP (Rattus norvegicus)
eNOS:NOSIP [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)
eNOS:NOSIP [Golgi membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Rattus norvegicus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS activation (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Depalmitoylation of eNOS (Rattus norvegicus)
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)
eNOS:Caveolin-1:CaM [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)
myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
eNOS associates with Caveolin-1 (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
GSR-2:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
XDH dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
XDH dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)
XDH dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Rattus norvegicus)
XDH dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Pyrimidine catabolism (Rattus norvegicus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)
DPYD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)
DPYD dimer [cytosol] (Rattus norvegicus)
FAD [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Cobalamin (Cbl) metabolism (Rattus norvegicus)
MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)
MTRR:MTR:MeCbl [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)
MTRR:MTR:MeCbl [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Rattus norvegicus)
MTRR:MTR [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Rattus norvegicus)
MTRR:MTR [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Rattus norvegicus)
MTRR:MTR [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
FAD [cytosol]
FLAD1 phosphorylates FMN (Rattus norvegicus)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Rattus norvegicus)
AOX1 oxidises PXL to PDXate (Rattus norvegicus)
2xAOX1:cofactors [cytosol] (Rattus norvegicus)
AOX1:cofactors [cytosol] (Rattus norvegicus)
FAD [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 complex:RAC1:GTP [plasma membrane] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
AKT1 phosphorylates eNOS (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)
eNOS:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)
eNOS:Caveolin-1:CaM [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate NADPH Oxidases (Rattus norvegicus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 complex:RAC1:GTP [plasma membrane] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
RHO GTPase cycle (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 binds effectors at the plasma membrane (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
NOX2 complex [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
FAD [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to mechanical stimuli (Saccharomyces cerevisiae)
Response of endothelial cells to shear stress (Saccharomyces cerevisiae)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Saccharomyces cerevisiae)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Saccharomyces cerevisiae)
p-S633-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Saccharomyces cerevisiae)
p-S1177,S1179-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
GSR-2:FAD dimer [cytosol] (Saccharomyces cerevisiae)
FAD [cytosol]
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
Generic Transcription Pathway (Saccharomyces cerevisiae)
Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
TP53 Regulates Metabolic Genes (Saccharomyces cerevisiae)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
GSR-2:FAD dimer [cytosol] (Saccharomyces cerevisiae)
FAD [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Metabolism of steroids (Saccharomyces cerevisiae)
Cholesterol biosynthesis (Saccharomyces cerevisiae)
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
SQLE:FAD [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
eNOS activation (Saccharomyces cerevisiae)
AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
eNOS:CaM:HSP90 [plasma membrane] (Saccharomyces cerevisiae)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Depalmitoylation of eNOS (Saccharomyces cerevisiae)
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)
myristoylated eNOS dimer [Golgi membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
FAD [cytosol]
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
GSR-2:FAD dimer [cytosol] (Saccharomyces cerevisiae)
FAD [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Saccharomyces cerevisiae)
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Vitamin B2 (riboflavin) metabolism (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
FAD [cytosol]
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
FAD [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
ESR-mediated signaling (Saccharomyces cerevisiae)
Extra-nuclear estrogen signaling (Saccharomyces cerevisiae)
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by VEGF (Saccharomyces cerevisiae)
VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
eNOS:CaM:HSP90 [plasma membrane] (Saccharomyces cerevisiae)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
FAD [cytosol]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to mechanical stimuli (Schizosaccharomyces pombe)
Response of endothelial cells to shear stress (Schizosaccharomyces pombe)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Schizosaccharomyces pombe)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Schizosaccharomyces pombe)
p-S633-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Schizosaccharomyces pombe)
p-S1177,S1179-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
GSR-2:FAD dimer [cytosol] (Schizosaccharomyces pombe)
FAD [cytosol]
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
GSR-2:FAD dimer [cytosol] (Schizosaccharomyces pombe)
FAD [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Metabolism of steroids (Schizosaccharomyces pombe)
Cholesterol biosynthesis (Schizosaccharomyces pombe)
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
SQLE:FAD [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Depalmitoylation of eNOS (Schizosaccharomyces pombe)
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)
myristoylated eNOS dimer [Golgi membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
FAD [cytosol]
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
GSR-2:FAD dimer [cytosol] (Schizosaccharomyces pombe)
FAD [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Vitamin B2 (riboflavin) metabolism (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
FAD [cytosol]
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
FAD [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
eNOS:CaM:HSP90 [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
FAD [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to mechanical stimuli (Sus scrofa)
Response of endothelial cells to shear stress (Sus scrofa)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Sus scrofa)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Sus scrofa)
p-S633-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Sus scrofa)
p-S1177,S1179-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Detoxification of Reactive Oxygen Species (Sus scrofa)
NOX2 generates superoxide from oxygen (Sus scrofa)
NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
Cytochrome b-245 [phagocytic vesicle membrane] (Sus scrofa)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
GSR-2:FAD dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
XDH oxidises 6MP to 6TU (Sus scrofa)
XDH dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
TP53 Regulates Metabolic Genes (Sus scrofa)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
GSR-2:FAD dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Hemostasis (Sus scrofa)
Factors involved in megakaryocyte development and platelet production (Sus scrofa)
MICAL1 produces NADP+, H2O2 (Sus scrofa)
MICAL1:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)
NQO2:FAD dimer [cytosol] (Sus scrofa)
NQO2:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
Phase II - Conjugation of compounds (Sus scrofa)
Methylation (Sus scrofa)
MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)
MTRR:MTR:MeCbl [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Sulfur amino acid metabolism (Sus scrofa)
MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)
MTRR:MTR:MeCbl [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Cholesterol biosynthesis (Sus scrofa)
Squalene is oxidized to its epoxide (Sus scrofa)
SQLE:FAD [endoplasmic reticulum membrane] (Sus scrofa)
FAD [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Sus scrofa)
NOSIP mediated eNOS trafficking (Sus scrofa)
eNOS binds NOSIP (Sus scrofa)
eNOS:NOSIP [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)
eNOS:NOSIP [Golgi membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
FAD [cytosol]
eNOS:NOSIP [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
NOSTRIN mediated eNOS trafficking (Sus scrofa)
NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Sus scrofa)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS activation (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
eNOS:CaM:HSP90 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Sus scrofa)
eNOS:CaM:HSP90 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Depalmitoylation of eNOS (Sus scrofa)
myristoylated eNOS dimer [cytosol] (Sus scrofa)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)
eNOS:Caveolin-1:CaM [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)
myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
FAD [cytosol]
myristoylated eNOS dimer [cytosol] (Sus scrofa)
FAD [cytosol]
eNOS associates with Caveolin-1 (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS translocation from Golgi to Caveolae (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
GSR-2:FAD dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Nucleotide catabolism (Sus scrofa)
Purine catabolism (Sus scrofa)
XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
XDH dimer [cytosol] (Sus scrofa)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Sus scrofa)
XDH dimer [cytosol] (Sus scrofa)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)
XDH dimer [cytosol] (Sus scrofa)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Sus scrofa)
XDH dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Pyrimidine catabolism (Sus scrofa)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)
DPYD dimer [cytosol] (Sus scrofa)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)
DPYD dimer [cytosol] (Sus scrofa)
FAD [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Sus scrofa)
Cobalamin (Cbl) metabolism (Sus scrofa)
MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)
MTRR:MTR:MeCbl [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)
MTRR:MTR:MeCbl [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:MeCbl [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Sus scrofa)
MTRR:MTR [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)
MTRR:MTR [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Sus scrofa)
MTRR:MTR [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
FAD [cytosol]
Vitamin B2 (riboflavin) metabolism (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
FAD [cytosol]
FLAD1 phosphorylates FMN (Sus scrofa)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Sus scrofa)
AOX1 oxidises PXL to PDXate (Sus scrofa)
2xAOX1:cofactors [cytosol] (Sus scrofa)
AOX1:cofactors [cytosol] (Sus scrofa)
FAD [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Extra-nuclear estrogen signaling (Sus scrofa)
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
VEGFR2 mediated vascular permeability (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
eNOS:CaM:HSP90 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Sus scrofa)
eNOS:CaM:HSP90 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)
eNOS:Caveolin-1:CaM [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Sus scrofa)
eNOS:Caveolin-1 [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate NADPH Oxidases (Sus scrofa)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
RHO GTPase cycle (Sus scrofa)
RAC1 GTPase cycle (Sus scrofa)
RAC1 binds effectors at the plasma membrane (Sus scrofa)
RAC1 effectors [cytosol] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Sus scrofa)
RAC1 effectors [cytosol] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
RAC3 GTPase cycle (Sus scrofa)
RAC3 binds effectors at the plasma membrane (Sus scrofa)
RAC3 effectors [cytosol] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Sus scrofa)
RAC3 effectors [cytosol] (Sus scrofa)
NOX2 complex [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
FAD [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
NOX2 complex [phagocytic vesicle membrane] (Xenopus tropicalis)
Cytochrome b-245 [phagocytic vesicle membrane] (Xenopus tropicalis)
FAD [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
GSR-2:FAD dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
XDH dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
TP53 Regulates Metabolic Genes (Xenopus tropicalis)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
GSR-2:FAD dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Hemostasis (Xenopus tropicalis)
Factors involved in megakaryocyte development and platelet production (Xenopus tropicalis)
MICAL1 produces NADP+, H2O2 (Xenopus tropicalis)
MICAL1:FAD [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)
NQO2:FAD dimer [cytosol] (Xenopus tropicalis)
NQO2:FAD [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Metabolism of steroids (Xenopus tropicalis)
Cholesterol biosynthesis (Xenopus tropicalis)
Squalene is oxidized to its epoxide (Xenopus tropicalis)
SQLE:FAD [endoplasmic reticulum membrane] (Xenopus tropicalis)
FAD [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Interconversion of nucleotide di- and triphosphates (Xenopus tropicalis)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
GSR-2:FAD dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Nucleotide catabolism (Xenopus tropicalis)
Purine catabolism (Xenopus tropicalis)
XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
XDH dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
XDH dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)
XDH dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
XDH oxidizes xanthine to form urate (Xenopus tropicalis)
XDH dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Pyrimidine catabolism (Xenopus tropicalis)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)
DPYD dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)
DPYD dimer [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Vitamin B2 (riboflavin) metabolism (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
FAD [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)
FAD [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Xenopus tropicalis)
AOX1 oxidises PXL to PDXate (Xenopus tropicalis)
2xAOX1:cofactors [cytosol] (Xenopus tropicalis)
AOX1:cofactors [cytosol] (Xenopus tropicalis)
FAD [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
NOX2 complex:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
Signaling by Rho GTPases (Xenopus tropicalis)
RHO GTPase Effectors (Xenopus tropicalis)
RHO GTPases Activate NADPH Oxidases (Xenopus tropicalis)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
NOX2 complex:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
RHO GTPase cycle (Xenopus tropicalis)
RAC1 GTPase cycle (Xenopus tropicalis)
RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)
RAC1 effectors [cytosol] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
RAC1:GTP:RAC1 effectors [plasma membrane] (Xenopus tropicalis)
RAC1 effectors [cytosol] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
RAC3 GTPase cycle (Xenopus tropicalis)
RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)
RAC3 effectors [cytosol] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
RAC3:GTP:RAC3 effectors [plasma membrane] (Xenopus tropicalis)
RAC3 effectors [cytosol] (Xenopus tropicalis)
NOX2 complex [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
FAD [cytosol]
External Reference Information
External Reference
FAD(3-) [ChEBI:57692]
Participates
as a component of
TAH18:FAD:FMN [cytosol] (Saccharomyces cerevisiae)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
MICAL1:FAD [cytosol] (Dictyostelium discoideum)
MICAL1:FAD [cytosol] (Danio rerio)
MICAL1:FAD [cytosol] (Sus scrofa)
MICAL1:FAD [cytosol] (Caenorhabditis elegans)
MICAL1:FAD [cytosol] (Gallus gallus)
MICAL1:FAD [cytosol] (Xenopus tropicalis)
MICAL1:FAD [cytosol] (Homo sapiens)
NQO2:FAD [cytosol] (Sus scrofa)
NQO2:FAD [cytosol] (Gallus gallus)
NQO2:FAD [cytosol] (Rattus norvegicus)
NQO2:FAD [cytosol] (Bos taurus)
NQO2:FAD [cytosol] (Canis familiaris)
NQO2:FAD [cytosol] (Mus musculus)
NQO2:FAD [cytosol] (Xenopus tropicalis)
NQO2:FAD [cytosol] (Homo sapiens)
mutant MTRR:FMN:FAD [cytosol] (Homo sapiens)
AOX1:cofactors [cytosol] (Xenopus tropicalis)
AOX1:cofactors [cytosol] (Caenorhabditis elegans)
AOX1:cofactors [cytosol] (Sus scrofa)
AOX1:cofactors [cytosol] (Dictyostelium discoideum)
AOX1:cofactors [cytosol] (Rattus norvegicus)
AOX1:cofactors [cytosol] (Bos taurus)
AOX1:cofactors [cytosol] (Gallus gallus)
AOX1:cofactors [cytosol] (Drosophila melanogaster)
AOX1:cofactors [cytosol] (Danio rerio)
AOX1:cofactors [cytosol] (Mus musculus)
AOX1:cofactors [cytosol] (Homo sapiens)
NQO1:FAD dimer [cytosol] (Homo sapiens)
p-S1177,S1179-eNOS dimer [plasma membrane] (Mus musculus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Sus scrofa)
p-S1177,S1179-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
p-S1177,S1179-eNOS dimer [plasma membrane] (Bos taurus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Rattus norvegicus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
p-S1177,S1179-eNOS dimer [plasma membrane] (Gallus gallus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Drosophila melanogaster)
p-S1177,S1179-eNOS dimer [plasma membrane] (Plasmodium falciparum)
p-S1177,S1179-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177,S1179-eNOS dimer [plasma membrane] (Homo sapiens)
p-S633-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
p-S633-eNOS dimer [plasma membrane] (Gallus gallus)
p-S633-eNOS dimer [plasma membrane] (Bos taurus)
p-S633-eNOS dimer [plasma membrane] (Mus musculus)
p-S633-eNOS dimer [plasma membrane] (Drosophila melanogaster)
p-S633-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S633-eNOS dimer [plasma membrane] (Sus scrofa)
p-S633-eNOS dimer [plasma membrane] (Plasmodium falciparum)
p-S633-eNOS dimer [plasma membrane] (Rattus norvegicus)
p-S633-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
p-S633-eNOS dimer [plasma membrane] (Homo sapiens)
LpdC dimer [cytosol] (Mycobacterium tuberculosis)
TrxB dimer [cytosol] (Mycobacterium tuberculosis)
2xTXNRD1:2xFAD [cytosol] (Bos taurus)
2xGsr-2:2xFAD [cytosol] (Rattus norvegicus)
SQLE:FAD [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
SQLE:FAD [endoplasmic reticulum membrane] (Xenopus tropicalis)
SQLE:FAD [endoplasmic reticulum membrane] (Gallus gallus)
SQLE:FAD [endoplasmic reticulum membrane] (Canis familiaris)
SQLE:FAD [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
SQLE:FAD [endoplasmic reticulum membrane] (Danio rerio)
SQLE:FAD [endoplasmic reticulum membrane] (Rattus norvegicus)
SQLE:FAD [endoplasmic reticulum membrane] (Dictyostelium discoideum)
SQLE:FAD [endoplasmic reticulum membrane] (Sus scrofa)
SQLE:FAD [endoplasmic reticulum membrane] (Bos taurus)
SQLE:FAD [endoplasmic reticulum membrane] (Mus musculus)
SQLE:FAD [endoplasmic reticulum membrane] (Homo sapiens)
DPYD dimer [cytosol] (Canis familiaris)
DPYD dimer [cytosol] (Mus musculus)
DPYD dimer [cytosol] (Drosophila melanogaster)
DPYD dimer [cytosol] (Dictyostelium discoideum)
DPYD dimer [cytosol] (Gallus gallus)
DPYD dimer [cytosol] (Bos taurus)
DPYD dimer [cytosol] (Xenopus tropicalis)
DPYD dimer [cytosol] (Caenorhabditis elegans)
DPYD dimer [cytosol] (Danio rerio)
DPYD dimer [cytosol] (Sus scrofa)
DPYD dimer [cytosol] (Rattus norvegicus)
DPYD dimer [cytosol] (Homo sapiens)
XDH dimer [cytosol] (Gallus gallus)
XDH dimer [cytosol] (Dictyostelium discoideum)
XDH dimer [cytosol] (Mus musculus)
XDH dimer [cytosol] (Canis familiaris)
XDH dimer [cytosol] (Rattus norvegicus)
XDH dimer [cytosol] (Xenopus tropicalis)
XDH dimer [cytosol] (Sus scrofa)
XDH dimer [cytosol] (Drosophila melanogaster)
XDH dimer [cytosol] (Bos taurus)
XDH dimer [cytosol] (Caenorhabditis elegans)
XDH dimer [cytosol] (Homo sapiens)
Cytochrome b-245 [phagocytic vesicle membrane] (Xenopus tropicalis)
Cytochrome b-245 [phagocytic vesicle membrane] (Mus musculus)
Cytochrome b-245 [phagocytic vesicle membrane] (Gallus gallus)
Cytochrome b-245 [phagocytic vesicle membrane] (Bos taurus)
Cytochrome b-245 [phagocytic vesicle membrane] (Canis familiaris)
Cytochrome b-245 [phagocytic vesicle membrane] (Rattus norvegicus)
Cytochrome b-245 [phagocytic vesicle membrane] (Danio rerio)
Cytochrome b-245 [phagocytic vesicle membrane] (Sus scrofa)
Cytochrome b-245 [phagocytic vesicle membrane] (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Sus scrofa)
GSR-2:FAD dimer [cytosol] (Caenorhabditis elegans)
GSR-2:FAD dimer [cytosol] (Plasmodium falciparum)
GSR-2:FAD dimer [cytosol] (Bos taurus)
GSR-2:FAD dimer [cytosol] (Canis familiaris)
GSR-2:FAD dimer [cytosol] (Rattus norvegicus)
GSR-2:FAD dimer [cytosol] (Dictyostelium discoideum)
GSR-2:FAD dimer [cytosol] (Gallus gallus)
GSR-2:FAD dimer [cytosol] (Saccharomyces cerevisiae)
GSR-2:FAD dimer [cytosol] (Xenopus tropicalis)
GSR-2:FAD dimer [cytosol] (Mus musculus)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Schizosaccharomyces pombe)
TNXRD1:FAD dimer [cytosol] (Plasmodium falciparum)
TNXRD1:FAD dimer [cytosol] (Gallus gallus)
TNXRD1:FAD dimer [cytosol] (Caenorhabditis elegans)
TNXRD1:FAD dimer [cytosol] (Mus musculus)
TNXRD1:FAD dimer [cytosol] (Bos taurus)
TNXRD1:FAD dimer [cytosol] (Rattus norvegicus)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Xenopus tropicalis)
Cytochrome b-245 [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Sus scrofa)
Cytochrome b-245 [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Rattus norvegicus)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
myristoylated eNOS dimer [Golgi membrane] (Saccharomyces cerevisiae)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
myristoylated eNOS dimer [Golgi membrane] (Schizosaccharomyces pombe)
myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Rattus norvegicus)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Sus scrofa)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Plasmodium falciparum)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Plasmodium falciparum)
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Mus musculus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
myristoylated eNOS dimer [cytosol] (Sus scrofa)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
as an input of
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
as an output of
FLAD1 phosphorylates FMN (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Gallus gallus)
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FLAD1 phosphorylates FMN (Danio rerio)
FLAD1 phosphorylates FMN (Sus scrofa)
FLAD1 phosphorylates FMN (Bos taurus)
FLAD1 phosphorylates FMN (Canis familiaris)
FLAD1 phosphorylates FMN (Rattus norvegicus)
FLAD1 phosphorylates FMN (Mus musculus)
FLAD1 phosphorylates FMN (Homo sapiens)
This entity regulates
Negatively
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Caenorhabditis elegans)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Drosophila melanogaster)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Gallus gallus)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Xenopus tropicalis)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Danio rerio)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Sus scrofa)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Bos taurus)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Canis familiaris)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Rattus norvegicus)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Homo sapiens)
SLC52A1,2,3 transport RIB from extracellular region to cytosol
(Mus musculus)
Other forms of this molecule
FAD [mitochondrial outer membrane]
FAD [endoplasmic reticulum membrane]
FAD [mitochondrial intermembrane space]
FAD [extracellular region]
FAD [endosome membrane]
FAD [mitochondrial inner membrane]
FAD [mitochondrial matrix]
FAD [peroxisomal matrix]
Cross References
COMPOUND
C00016
ZINC
ZINC000008215434
,
ZINC000195756838
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