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p-S1177-eNOS dimer [plasma membrane]
Stable Identifier
R-HSA-203564
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(Homo sapiens)
x 2
BH4 [cytosol]
x 2
FAD [cytosol]
x 2
FMN [cytosol]
x 2
heme [cytosol]
Zn2+ [cytosol]
Participates
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
Inferred To
p-S1177-eNOS dimer [plasma membrane]
(Bos taurus)
p-S1177-eNOS dimer [plasma membrane]
(Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane]
(Canis familiaris)
p-S1177-eNOS dimer [plasma membrane]
(Danio rerio)
p-S1177-eNOS dimer [plasma membrane]
(Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane]
(Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane]
(Gallus gallus)
p-S1177-eNOS dimer [plasma membrane]
(Mus musculus)
p-S1177-eNOS dimer [plasma membrane]
(Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane]
(Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane]
(Schizosaccharomyces pombe)
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