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p-S1177-eNOS dimer [plasma membrane]
Stable Identifier
R-SPO-203564
Type
Complex
Species
Schizosaccharomyces pombe
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to mechanical stimuli (Schizosaccharomyces pombe)
Response of endothelial cells to shear stress (Schizosaccharomyces pombe)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Schizosaccharomyces pombe)
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
Metabolism (Schizosaccharomyces pombe)
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
Signal Transduction (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
BH4 [cytosol]
x 2
FAD [cytosol]
x 2
ferroheme [cytosol]
x 2
FMN [cytosol]
x 2
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(Schizosaccharomyces pombe)
Zn2+ [cytosol]
Participates
as an input of
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Schizosaccharomyces pombe)
as an output of
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Schizosaccharomyces pombe)
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
Inferred From
p-S1177-eNOS dimer [plasma membrane]
(Homo sapiens)
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