Reactome | PPP3CB [cytosol]

PPP3CB [cytosol]

Stable Identifier

R-CFA-2025869

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

PPP3CB, A0A8I3MW99

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Signaling by the B Cell Receptor (BCR) (Canis familiaris)
    - Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
      - Calcineurin activates NFAT (Canis familiaris)
        
        Calcineurin binds NFATC1,2,3 (Canis familiaris)
        
        Calcineurin (CaN) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Calcineurin:p-NFATC1,2,3 [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - C-type lectin receptors (CLRs) (Canis familiaris)
    - CLEC7A (Dectin-1) signaling (Canis familiaris)
      - CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
        
        Activation of Calcineurin (Canis familiaris)
        
        Calcineurin (CaN) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        NFAT:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
        
        NFAT:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated Ca+2 mobilization (Canis familiaris)
      - Activation of Calcineurin (Canis familiaris)
        
        Calcineurin (CaN) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
      - Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        NFAT:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
      - Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
        
        NFAT:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by WNT (Canis familiaris)
  - Beta-catenin independent WNT signaling (Canis familiaris)
    - Ca2+ pathway (Canis familiaris)
      - Activation of Calcineurin (Canis familiaris)
        
        Calcineurin (CaN) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
      - Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
        
        NFATC1:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)
      - Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
        
        NFATC1:CaN:CaM [cytosol] (Canis familiaris)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
        
        PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
        
        PPP3CA,B [cytosol] (Canis familiaris)
        
        PPP3CB [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MW99

Gene Names

PPP3CB

Reference Genes

BioGPS Gene:479248 PPP3CB

ENSEMBL:ENSCAFG00845007219.1

Monarch:479248 PPP3CB

NCBI Gene:479248 PPP3CB

UCSC:A0A8I3MW99 PPP3CB

Reference Transcript

Other Identifiers

479248

Cfa.18975.1.S1_s_at

GO:0001913

GO:0001915

GO:0001946

GO:0002376

GO:0003824

GO:0004721

GO:0004722

GO:0004723

GO:0005509

GO:0005516

GO:0005737

GO:0005886

GO:0005955

GO:0006355

GO:0006950

GO:0007040

GO:0007507

GO:0010468

GO:0016192

GO:0016787

GO:0017156

GO:0019899

GO:0023057

GO:0030018

GO:0030154

GO:0030217

GO:0030315

GO:0030346

GO:0031987

GO:0033173

GO:0033192

GO:0034097

GO:0035774

GO:0043029

GO:0045824

GO:0045944

GO:0046872

GO:0046983

GO:0048741

GO:0048856

GO:0097720

GO:0098978

GO:0140096

GO:0140367

GO:1900181

GO:1900182

GO:1900242

GO:1905673

Participates

as a member of

PPP3CA,B [cytosol] (Canis familiaris)

Other forms of this molecule

PPP3CB [nucleoplasm]

Inferred From

PPP3CB [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038390287.1, XP_005619088.1, XP_038518883.1

ENSEMBL

ENSCAFG00845007219, ENSCAFT00845012792, ENSCAFP00845009974

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