Reactome | PPP3CB [cytosol]

PPP3CB [cytosol]

Stable Identifier

R-DME-2025869

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

P48456

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
    - Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
      - Calcineurin activates NFAT (Drosophila melanogaster)
        
        Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)
        
        Calcineurin (CaN) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Calcineurin:p-NFATC1,2,3 [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - C-type lectin receptors (CLRs) (Drosophila melanogaster)
    - CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
      - CLEC7A (Dectin-1) induces NFAT activation (Drosophila melanogaster)
        
        Activation of Calcineurin (Drosophila melanogaster)
        
        Calcineurin (CaN) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        NFAT:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
        
        NFAT:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
  - Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
    - FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
      - Activation of Calcineurin (Drosophila melanogaster)
        
        Calcineurin (CaN) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
      - Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        NFAT:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
      - Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
        
        NFAT:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by WNT (Drosophila melanogaster)
  - Beta-catenin independent WNT signaling (Drosophila melanogaster)
    - Ca2+ pathway (Drosophila melanogaster)
      - Activation of Calcineurin (Drosophila melanogaster)
        
        Calcineurin (CaN) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
      - Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
        
        NFATC1:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)
      - Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)
        
        NFATC1:CaN:CaM [cytosol] (Drosophila melanogaster)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Calmodulin [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Drosophila melanogaster)
        
        PPP3CA,B [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP3CB [cytosol] (Drosophila melanogaster)
        
        PPP3CB [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P48456

Reference Genes

BioGPS Gene:43670

ENSEMBL:FBgn0010015

Flybase:FBgn0010015

KEGG Gene (Drosophila melanogaster):Dmel_CG1455

Monarch:43670

NCBI Gene:43670

Reference Transcript

Other Identifiers

143579_at

1632216_at

43670

GO:0002376

GO:0003824

GO:0004721

GO:0004722

GO:0004723

GO:0005516

GO:0005737

GO:0005955

GO:0006470

GO:0008021

GO:0016787

GO:0017018

GO:0023052

GO:0030431

GO:0031410

GO:0033192

GO:0036211

GO:0042059

GO:0043226

GO:0045088

GO:0046872

GO:0050877

GO:0071731

GO:0072375

GO:0097720

GO:0098542

GO:0140096

GO:0140460

Participates

as a member of

Homologues of PPP3CB [cytosol] (Drosophila melanogaster)

Other forms of this molecule

PPP3CB [nucleoplasm]

Inferred From

PPP3CB [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001247378.2, NP_524600.3

Flybase

FBgn0010015

PRO

P48456

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