Dermatan sulfate biosynthesis

Stable Identifier
R-HSA-2022923
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Dermatan sulfate biosynthesis
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Dermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues can be sulfated in CS chains but also the uronic acid
residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002).
Literature References
PubMed ID Title Journal Year
12512856 Biosynthesis of chondroitin/dermatan sulfate

Sugumaran, G, Silbert, JE

IUBMB Life 2002
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Event Information
Go Biological Process
dermatan sulfate biosynthetic process (0030208)
Orthologous Events
Dermatan sulfate biosynthesis (Bos taurus)
Dermatan sulfate biosynthesis (Canis familiaris)
Dermatan sulfate biosynthesis (Danio rerio)
Dermatan sulfate biosynthesis (Drosophila melanogaster)
Dermatan sulfate biosynthesis (Gallus gallus)
Dermatan sulfate biosynthesis (Mus musculus)
Dermatan sulfate biosynthesis (Rattus norvegicus)
Dermatan sulfate biosynthesis (Sus scrofa)
Dermatan sulfate biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-01)
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