DS-GAG biosynthesis

Stable Identifier
R-HSA-2022923
Type
Pathway
Species
Homo sapiens
Synonyms
Dermatan sulfate biosynthesis
ReviewStatus
5/5
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DS-GAG biosynthesis
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Dermatan sulfate (DS) glycosaminoglycan chains consist of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. They are bound to the tetrasaccharide linker moiety of core proteins. As with CS, GalNAc residues can be sulfated in DS chains but also the uronic acid residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002; reviewed in Mikami & Kitagawa, 2013).
Literature References
PubMed ID Title Journal Year
12512856 Biosynthesis of chondroitin/dermatan sulfate

Silbert, JE, Sugumaran, G

IUBMB Life 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
dermatan sulfate proteoglycan biosynthetic process (0050651)
Orthologous Events
DS-GAG biosynthesis (Bos taurus)
DS-GAG biosynthesis (Canis familiaris)
DS-GAG biosynthesis (Danio rerio)
DS-GAG biosynthesis (Drosophila melanogaster)
DS-GAG biosynthesis (Gallus gallus)
DS-GAG biosynthesis (Mus musculus)
DS-GAG biosynthesis (Rattus norvegicus)
DS-GAG biosynthesis (Sus scrofa)
DS-GAG biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
D'Eustachio, P  (2025-03-12)
Created
Jassal, B  (2011-12-01)
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