The glucuronate (GlcA) moiety of chondroitin sulfate (CS) can undergo C-5 epimerization to change into an iduronic acid (IdoA) moiety, thus changing the polymer composition and creating dermatan sulfate (DS). The GlcA of unsulfated chondroitin chains can also undergo this C-5 epimerization to produce dermatan. Dermatan-sulfate epimerase (DSE) mediates these reactions (Tiedemann et al. 2001). More recently, a single homologue of DSE, dermatan sulfate epimerase-like (DSEL), has been determined to possess epimerase activity (Pacheco et al. 2009). DSEL is genetically associated with type II bipolar disorder (Goossens et al. 2003).
Larsson, T, Tiedemann, K, Malmström, A, Heinegård, D
Pacheco, B, Malmström, A, Maccarana, M
Aebersold, R, Maccarana, M, Li, JP, Malmström, J, Tiedemann, K, Olander, B, Malmström, A, Lindahl, U
Backhovens, H, Claes, S, Van Broeckhoven, C, Van den Bossche, D, Mendlewicz, J, Van Gestel, S, Massat, I, De Rijk, P, Del-Favero, J, Goossens, D, Souery, D
chondroitin-glucuronate 5-epimerase activity of DSE,DSEL [Golgi membrane]
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