Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

Stable Identifier
R-HSA-2022052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The glucuronate (GlcA) moiety of chondroitin sulfate (CS) can undergo C-5 epimerization to change into an iduronic acid (IdoA) moiety, thus changing the polymer composition and creating dermatan sulfate (DS). The GlcA of unsulfated chondroitin chains can also undergo this C-5 epimerization to produce dermatan. Dermatan-sulfate epimerase (DSE) mediates these reactions (Tiedemann et al. 2001). More recently, a single homologue of DSE, dermatan sulfate epimerase-like (DSEL), has been determined to possess epimerase activity (Pacheco et al. 2009). DSEL is genetically associated with type II bipolar disorder (Goossens et al. 2003).

Literature References
PubMed ID Title Journal Year
19188366 Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate

Pacheco, B, Malmström, A, Maccarana, M

J. Biol. Chem. 2009
11414686 The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis

Tiedemann, K, Larsson, T, Heinegård, D, Malmström, A

Arch Biochem Biophys 2001
16505484 Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2

Maccarana, M, Olander, B, Malmström, J, Tiedemann, K, Aebersold, R, Lindahl, U, Li, JP, Malmström, A

J Biol Chem 2006
12556911 A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder

Goossens, D, Van Gestel, S, Claes, S, De Rijk, P, Souery, D, Massat, I, Van den Bossche, D, Backhovens, H, Mendlewicz, J, Van Broeckhoven, C, Del-Favero, J

Mol. Psychiatry 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
chondroitin-glucuronate 5-epimerase activity of DSE,DSEL [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created