Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

Stable Identifier
R-HSA-2022052
Type
Reaction
Species
Homo sapiens
Compartment
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The glucuronate (GlcA) moiety of chondroitin sulfate (CS) can undergo C-5 epimerization to change into an iduronic acid (IdoA) moiety, thus changing the polymer composition and creating dermatan sulfate (DS). The GlcA of unsulfated chondroitin chains can also undergo this C-5 epimerization to produce dermatan. Dermatan-sulfate epimerase (DSE) mediates these reactions (Tiedemann et al. 2001). More recently, a single homologue of DSE, dermatan sulfate epimerase-like (DSEL), has been determined to possess epimerase activity (Pacheco et al. 2009). DSEL is genetically associated with type II bipolar disorder (Goossens et al. 2003).

Literature References
PubMed ID Title Journal Year
11414686 The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis

Larsson, T, Tiedemann, K, Malmström, A, Heinegård, D

Arch Biochem Biophys 2001
19188366 Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate

Pacheco, B, Malmström, A, Maccarana, M

J. Biol. Chem. 2009
16505484 Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2

Aebersold, R, Maccarana, M, Li, JP, Malmström, J, Tiedemann, K, Olander, B, Malmström, A, Lindahl, U

J Biol Chem 2006
12556911 A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder

Backhovens, H, Claes, S, Van Broeckhoven, C, Van den Bossche, D, Mendlewicz, J, Van Gestel, S, Massat, I, De Rijk, P, Del-Favero, J, Goossens, D, Souery, D

Mol. Psychiatry 2003
Participants
Participates
Catalyst Activity

chondroitin-glucuronate 5-epimerase activity of DSE,DSEL [Golgi membrane]

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