CHST15 transfers sulfate to (6-)GalNAc-4-sulfate

Stable Identifier
R-HSA-9941312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
Synonyms
Dermatan 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
ReviewStatus
5/5
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CHST15 transfers sulfate to (6-)GalNAc-4-sulfate
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Carbohydrate sulfotransferase 15 (CHST15) catalyses the transfer of one or more sulfate ions from PAPS to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of dermatan 4-sulfate (C4S) (Ohtake et al. 2003).
Literature References
PubMed ID Title Journal Year
12874280 A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase

Ohtake, S, Kimata, K, Habuchi, O

J Biol Chem 2003
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Catalyst Activity

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity of CHST15 [Golgi membrane]

Physical Entity
CHST15 [Golgi membrane] (Homo sapiens)
Activity
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity (GO:0050659)
Orthologous Events
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Bos taurus)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Danio rerio)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Gallus gallus)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Mus musculus)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Rattus norvegicus)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Sus scrofa)
CHST15 transfers sulfate to (6-)GalNAc-4-sulfate (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2025-02-18)
Reviewed
D'Eustachio, P  (2025-05-15)
Created
Stephan, R  (2025-03-07)
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